Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 15/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 15/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9013742 | 0.88 | MEN1 (0.46) | MEN1KMT2AHCRTR1GAAMAPT | |
| SCHEMBL8716448 | 0.85 | KMT2A (0.64) | MEN1KMT2AHCRTR1GAAMAPT | |
| SCHEMBL9013774 | 0.83 | MEN1 (0.60) | MEN1KMT2AHCRTR1GAAMAPT | |
| SCHEMBL8698121 | 0.82 | MEN1 (0.73) | MEN1KMT2AHCRTR1GAAMAPT | |
| SCHEMBL8672827 | 0.81 | MEN1 (0.48) | MEN1KMT2AHCRTR1GAACYP3A4 | |
| SCHEMBL8476145 | 0.76 | LMNA (0.46) | MEN1KMT2AGAAMAPT | |
| SCHEMBL9013933 | 0.75 | KMT2A (0.53) | MEN1KMT2AHCRTR1GAACYP3A4 | |
| SCHEMBL8527399 | 0.75 | KMT2A (0.43) | MEN1KMT2AGAAMAPT | |
| SCHEMBL8479040 | 0.74 | KMT2A (0.44) | MEN1KMT2AGAAMAPT | |
| SCHEMBL8475279 | 0.74 | KMT2A (0.60) | MEN1KMT2AHCRTR1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876355-A1 | 2-THIOXO-IMIDAZOLIDIN-4-ONE DERIVATIVES AND THEIR USE FOR INCREASING HDL CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-11-11 | — | — | EP | claimed |
| WO-1997019932-A1 | 2-THIOXO-IMIDAZOLIDIN-4-ONE DERIVATIVES AND THEIR USE FOR INCREASING HDL CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-06-05 | — | — | WO | claimed |
| US-5554607-A | INCREASING HDL CHOLESTEROL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-09-10 | — | — | US | disclosed |