Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8716607 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAHTTNAMPTSLC18A3 | |
| SCHEMBL8710895 | 0.95 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAHTTNAMPTSLC18A3 | |
| Fumaric Acid SCHEMBL8714585 | 0.92 | MEN1 (0.45) | SMN1; SMN2LMNAHTTNAMPTSLC18A3 | |
| Fumaric Acid SCHEMBL8714590 | 0.92 | MEN1 (0.45) | SMN1; SMN2LMNAHTTNAMPTSLC18A3 | |
| Fumaric Acid SCHEMBL8711361 | 0.90 | LMNA (0.46) | SMN1; SMN2LMNAHTTNAMPTSLC18A3 | |
| Fumaric Acid SCHEMBL8711360 | 0.90 | LMNA (0.46) | SMN1; SMN2LMNAHTTNAMPTSLC18A3 | |
| SCHEMBL8713817 | 0.87 | MEN1 (0.49) | SMN1; SMN2LMNAHTTNAMPTSLC18A3 | |
| Fumaric Acid SCHEMBL8711107 | 0.86 | PTGIR (0.44) | SMN1; SMN2LMNANAMPTACHEHTR2A | |
| SCHEMBL8711207 | 0.86 | LMNA (0.49) | SMN1; SMN2LMNAHTTNAMPTSLC18A3 | |
| Fumaric Acid SCHEMBL8711104 | 0.86 | PTGIR (0.44) | SMN1; SMN2LMNANAMPTACHEHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |