Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 3/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 9/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720241 | 0.91 | OPRD1 (0.60) | OPRD1OPRK1MTNR1BKEAP1NFE2L2 | |
| SCHEMBL8717575 | 0.86 | OPRD1 (0.45) | OPRD1OPRK1MTNR1BKEAP1NFE2L2 | |
| SCHEMBL8717029 | 0.77 | OPRD1 (0.55) | OPRD1OPRK1MTNR1BKEAP1NFE2L2 | |
| SCHEMBL8717350 | 0.75 | OPRK1 (0.60) | OPRD1OPRK1KEAP1NFE2L2ATM | |
| SCHEMBL8717410 | 0.75 | HRH3 (0.56) | OPRD1 | |
| SCHEMBL8719963 | 0.73 | OPRK1 (0.55) | OPRD1OPRK1KEAP1NFE2L2ATM | |
| SCHEMBL27401731 | 0.73 | OPRK1 (0.55) | OPRD1OPRK1KEAP1NFE2L2ATM | |
| SCHEMBL10434728 | 0.72 | OPRD1 (0.63) | OPRD1OPRK1MTNR1BKEAP1NPSR1 | |
| SCHEMBL13110444 | 0.72 | OPRK1 (0.80) | OPRD1OPRK1KEAP1NFE2L2ATM | |
| SCHEMBL9815296 | 0.72 | OPRD1 (0.76) | OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569802-B1 | Arylacetamides | MERCK PATENT GMBH (DE) | 1998-07-15 | — | — | EP | claimed |
| EP-0569802-A1 | Arylacetamides | MERCK PATENT GmbH (DE) | 1993-11-18 | — | — | EP | claimed |
| EP-0569802-B1 | Arylacetamides | MERCK PATENT GMBH (DE) | 1998-07-15 | — | — | EP | disclosed |
| US-5532266-A | Acrylacetamides | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-02 | — | — | US | disclosed |
| EP-0569802-A1 | Arylacetamides | MERCK PATENT GmbH (DE) | 1993-11-18 | — | — | EP | disclosed |