Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 9/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27401731 | 1.00 | OPRK1 (0.55) | OPRK1OPRD1ALDH1A1NPSR1KEAP1 | |
| SCHEMBL8717350 | 0.87 | OPRK1 (0.60) | OPRK1OPRD1ALDH1A1NPSR1KEAP1 | |
| SCHEMBL8717277 | 0.86 | ALDH1A1 (0.45) | OPRK1OPRD1ALDH1A1NPSR1KEAP1 | |
| SCHEMBL8717561 | 0.78 | HRH3 (0.53) | ALDH1A1NPSR1CCR1 | |
| SCHEMBL13110444 | 0.76 | OPRK1 (0.80) | OPRK1OPRD1ALDH1A1NPSR1KEAP1 | |
| SCHEMBL8717029 | 0.74 | OPRD1 (0.55) | OPRK1OPRD1ALDH1A1NPSR1KEAP1 | |
| SCHEMBL8722168 | 0.73 | ALDH1A1 (0.52) | OPRK1OPRD1ALDH1A1NPSR1KEAP1 | |
| SCHEMBL8716975 | 0.73 | OPRD1 (0.59) | OPRK1OPRD1ALDH1A1NPSR1KEAP1 | |
| SCHEMBL10434728 | 0.72 | OPRD1 (0.63) | OPRK1OPRD1ALDH1A1NPSR1KEAP1 | |
| SCHEMBL9815296 | 0.72 | OPRD1 (0.76) | OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1041087-C | Arylacetamides | MERCK PATENT AG (DE) | 1998-12-09 | — | — | CN | disclosed |
| EP-0569802-B1 | Arylacetamides | MERCK PATENT GMBH (DE) | 1998-07-15 | — | — | EP | disclosed |
| US-5532266-A | Acrylacetamides | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-02 | — | — | US | disclosed |
| EP-0569802-A1 | Arylacetamides | MERCK PATENT GmbH (DE) | 1993-11-18 | — | — | EP | disclosed |