SCHEMBL8718016

SCHEMBL8718016

O=C1C(Cl)=C(Cl)C(=O)N1c1ccc(Cl)cc1.O=C1OC(=O)C(Cl)=C1Cl

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.58
KMT2A Q03164 3/20 0.58
RAD51 Q06609 1/20 0.51
POLB P06746 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
MGLL Q99685 1/20 0.48
ALDH1A1 P00352 1/20 0.47
MAPT P10636 1/20 0.47
ALOX12 P18054 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.45
ELANE P08246 2/20 0.44
NPC1 O15118 1/20 0.43
USP2 O75604 1/20 0.43
RAB9A P51151 1/20 0.43
ATM Q13315 1/20 0.43
KEAP1 Q14145 1/20 0.43
NFE2L2 Q16236 1/20 0.43
PGR P06401 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8504879 0.88 MEN1 (0.65) MEN1KMT2ARAD51POLBL3MBTL1
SCHEMBL2488181 0.74 ALDH1A1 (0.59) MEN1KMT2ARAD51L3MBTL1MGLL
SCHEMBL29481075 0.74 KMT2A (1.00) MEN1KMT2AMGLLNPC1USP2
SCHEMBL3627957 0.74 KMT2A (1.00) MEN1KMT2AMGLLNPC1USP2
SCHEMBL15437731 0.73 RAD51 (0.69) MEN1KMT2ARAD51POLBL3MBTL1
Fluoroimide SCHEMBL68964 0.71 MGLL (0.56) MEN1KMT2APOLBL3MBTL1MGLL
SCHEMBL10834478 0.71 FAAH (0.56) MEN1KMT2ARAD51POLBL3MBTL1
SCHEMBL10834894 0.71 MEN1 (0.61) MEN1KMT2ARAD51POLBL3MBTL1
SCHEMBL15347079 0.70 KMT2A (0.69) MEN1KMT2ARAD51POLBL3MBTL1
SCHEMBL11117005 0.70 MGLL (0.60) MEN1KMT2ARAD51POLBL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0830430-A1 POLYMERS FOR ANTIFOULING COATINGS AND A PROCESS FOR THE PREPARATION THEREOF Jotun A/S (NO) 1998-03-25 EP disclosed
WO-1996041841-A1 POLYMERS FOR ANTIFOULING COATINGS AND A PROCESS FOR THE PREPARATION THEREOF JOTUN A/S (NO) 1996-12-27 WO disclosed