Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 15/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 13/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9242534 | 0.78 | MTNR1B (0.42) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL27640871 | 0.73 | HTR1A (0.54) | HTR1ASLC6A4 | |
| SCHEMBL6309751 | 0.72 | HTR1A (0.46) | HTR1ASLC6A4HPGD | |
| SCHEMBL7936073 | 0.71 | HTR1A (0.45) | HTR1ASLC6A4HPGD | |
| SCHEMBL19991886 | 0.68 | TSHR (0.41) | HPGD | |
| Cadaverine Tartrate SCHEMBL6245775 | 0.67 | HTR1A (0.41) | HTR1ASLC6A4HPGD | |
| SCHEMBL5472781 | 0.67 | POLB (0.40) | HTR1ASLC6A4HPGDSMN1; SMN2 | |
| SCHEMBL8242266 | 0.67 | ACHE (0.38) | HTR1ASLC6A4 | |
| SCHEMBL5763858 | 0.66 | HPGD (0.47) | HPGDSMN1; SMN2 | |
| SCHEMBL138644 | 0.66 | ACHE (0.36) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0822813-A1 | A COMBINATION OF A 5-HT UPTAKE INHIBITOR WITH A SELECTIVE 5-HT 1A? ANTAGONIST | Astra Aktiebolag (SE) | 1998-02-11 | — | — | EP | disclosed |
| WO-1996033710-A1 | A COMBINATION OF A 5-HT UPTAKE INHIBITOR WITH A SELECTIVE 5-HT1A ANTAGONIST | ASTRA AKTIEBOLAG (SE) | 1996-10-31 | — | — | WO | disclosed |