SCHEMBL8718078

SCHEMBL8718078

OB(O)OC(c1ccc(-c2ccccc2F)cc1)(c1ccc(-c2ccccc2F)cc1)c1ccc(-c2ccccc2F)c(-c2ccccc2F)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPRC P08575 1/20 0.40
PTPN1 P18031 1/20 0.40
PDK2 Q15119 1/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
SCD O00767 1/20 0.35
NPC1 O15118 1/20 0.34
PKM P14618 1/20 0.34
RAB9A P51151 1/20 0.34
ACMSD Q8TDX5 1/20 0.34
ERN1 O75460 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
PPARG P37231 1/20 0.32
PPARA Q07869 1/20 0.32
APP P05067 1/20 0.32
PTGDR2 Q9Y5Y4 1/20 0.32
ALOX5AP P20292 2/20 0.32
FEN1 P39748 2/20 0.32
BACE1 P56817 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8714275 0.81 PDK2 (0.37) PDK2PPARGPPARABACE1TRPA1
SCHEMBL4243980 0.80
SCHEMBL911318 0.79 MGLL (0.35) PDK2PTGDR2BACE1
SCHEMBL8718917 0.77 PDK2 (0.33) PDK2
SCHEMBL4251846 0.74 ANPEP (0.30)
SCHEMBL4246248 0.72 RXRA (0.31)
SCHEMBL8718057 0.72 PTPN1 (0.44) PTPN1PDK2MAPTNPC1RAB9A
SCHEMBL455817 0.69 RXRA (0.41) BACE1AKR1C3AKR1C2
SCHEMBL2316126 0.67 CA1 (0.56) PTPRCPTPN1PDK2ALDH1A1MAPT
Benzene SCHEMBL27568485 0.66 KIF11 (0.40) PTPN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9862783-B2 Imine compound, novel catalyst for olefin polymerization, and process for producing olefin polymer JAPAN POLYPROPYLENE CORPORATION (JP) 2018-01-09 US disclosed
US-20160237184-A1 IMINE COMPOUND, NOVEL CATALYST FOR OLEFIN POLYMERIZATION, AND PROCESS FOR PRODUCING OLEFIN POLYMER JAPAN POLYPROPYLENE CORPORATION (JP) 2016-08-18 US disclosed
EP-3050892-A1 IMINE COMPOUND AND NOVEL CATALYST FOR OLEFIN POLYMERIZATION, AND METHOD FOR PRODUCING OLEFIN POLYMER Japan Polypropylene Corporation (JP) 2016-08-03 EP disclosed
US-5744678-A NICKEL COMPOUND, ORGANOPHOSPHORUS COMPOUND, ORGANOALUMINUM COMPOUND, CARBON-HALOGEN COMPOUNDS; CATALYST SELECTIVITY NIPPON OIL CO., LTD. (JP) 1998-04-28 US disclosed
EP-0758563-A1 OLEFIN OLIGOMERIZATION CATALYST AND PROCESS FOR THE PREPARATION OF OLEFIN OLIGOMER USING IT NIPPON OIL COMPANY, LTD. (JP) 1997-02-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160237184-A1 IMINE COMPOUND, NOVEL CATALYST FOR OLEFIN POLYMERIZATION, AND PROCESS FOR PRODUCING OLEFIN POLYMER ODC1, MACF1, MOGAT2 PTPRC 4694/4885PTPN1 4836/4885PDK2 245/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.