Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.64 |
| ▸ | PPARA | Q07869 | 2/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | XDH | P47989 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26564978 | 0.89 | PARP15 (0.54) | EGLN1PPARAEPHX2XDHMEN1 | |
| SCHEMBL8407408 | 0.84 | ROCK2 (0.59) | EGLN1XDHMEN1KMT2AKDM4E | |
| SCHEMBL8407717 | 0.82 | HDAC3 (0.53) | EGLN1PPARAMEN1KMT2AMAPK1 | |
| SCHEMBL8947242 | 0.82 | KMT2A (0.67) | XDHMEN1KMT2AKDM4EGAA | |
| SCHEMBL5632141 | 0.81 | RAB9A (0.67) | EPHX2MEN1KMT2AKDM4EGAA | |
| SCHEMBL1921655 | 0.80 | EGLN1 (0.65) | EGLN1XDHKDM4EGAAMAPK1 | |
| SCHEMBL26568178 | 0.80 | KMT2A (0.59) | EPHX2MEN1KMT2AKDM4EGAA | |
| SCHEMBL8407405 | 0.79 | MAPT (0.65) | EGLN1MEN1KMT2AKDM4EGAA | |
| SCHEMBL9269300 | 0.79 | RAB9A (0.48) | EGLN1PPARAEPHX2MEN1KMT2A | |
| SCHEMBL1921875 | 0.79 | EGLN1 (1.00) | EGLN1FLT1EGLN3VEGFA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |