Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8722858 | 1.00 | KDM4E (0.42) | KDM4EHRH3SLC6A4L3MBTL1HRH1 | |
| SCHEMBL8722860 | 1.00 | KDM4E (0.42) | KDM4EHRH3SLC6A4L3MBTL1HRH1 | |
| SCHEMBL7424654 | 0.89 | SLC6A3 (0.45) | HRH3SIGMAR1SLC6A3 | |
| SCHEMBL7424665 | 0.89 | SLC6A3 (0.45) | HRH3SIGMAR1SLC6A3 | |
| SCHEMBL7422049 | 0.89 | SLC6A3 (0.45) | HRH3SIGMAR1SLC6A3 | |
| SCHEMBL8717975 | 0.86 | SLC18A2 (0.39) | HRH3SLC6A4L3MBTL1HRH1SIGMAR1 | |
| SCHEMBL7414244 | 0.86 | SLC18A2 (0.39) | HRH3SLC6A4L3MBTL1HRH1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8720630 | 0.85 | SLC18A2 (0.38) | HRH3L3MBTL1HRH1SIGMAR1SLC18A2 | |
| SCHEMBL7419970 | 0.85 | L3MBTL1 (0.45) | SLC6A4L3MBTL1HTR1ADRD2DRD1 | |
| SCHEMBL7413506 | 0.85 | HRH3 (0.40) | HRH3L3MBTL1HRH1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558487-B1 | PIPERIDINE COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1998-10-07 | — | — | EP | claimed |
| EP-0558487-B1 | PIPERIDINE COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1998-10-07 | — | — | EP | disclosed |
| US-5328917-A | Aminoalkyl and phenyl substituted hydrogenated pyridines | NOVO NORDISK A/S (DK) | 1994-07-12 | — | — | US | disclosed |
| EP-0558487-A1 | PIPERIDINE COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-09-08 | — | — | EP | disclosed |