Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | TACR1 | P25103 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7563807 | 0.85 | ALDH1A1 (0.61) | KCNJ1ALDH1A1KDM4ESMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL7564284 | 0.84 | KCNJ1 (0.58) | KCNJ1ALDH1A1KDM4ESMN1; SMN2HTT | |
| SCHEMBL21044045 | 0.83 | CTSB (0.68) | ALDH1A1KDM4ESMN1; SMN2HTTMEN1 | |
| SCHEMBL8714933 | 0.83 | CTSB (0.68) | ALDH1A1KDM4ESMN1; SMN2HTTMEN1 | |
| SCHEMBL7422612 | 0.82 | TACR1 (0.58) | KCNJ1ALDH1A1KDM4ESMN1; SMN2HTT | |
| SCHEMBL922716 | 0.81 | KCNJ1 (0.74) | KCNJ1ALDH1A1KDM4ESMN1; SMN2HTT | |
| SCHEMBL8715361 | 0.81 | KCNJ1 (0.55) | KCNJ1ALDH1A1KDM4ESMN1; SMN2HTT | |
| SCHEMBL6548611 | 0.80 | TACR1 (0.53) | ALDH1A1KDM4ETACR1MEN1KMT2A | |
| SCHEMBL20272178 | 0.79 | MAPT (0.60) | KCNJ1ALDH1A1KDM4ESMN1; SMN2HTT | |
| SCHEMBL8658728 | 0.79 | ALDH1A1 (0.48) | KCNJ1ALDH1A1KDM4ESMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353450-B1 | Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates | DOW CHEMICAL CO (US) | 1995-03-29 | — | — | EP | claimed |
| US-5756065-A | DIAGNOSTIC CHELATES FOR ANTIBODIES AND RADIOACTIVE MATERIALS | THE DOW CHEMICAL COMPANY (US) | 1998-05-26 | — | — | US | disclosed |
| US-5652361-A | ANTITUMOR | THE DOW CHEMICAL COMPANY (US) | 1997-07-29 | — | — | US | disclosed |
| US-5435990-A | Chelate-antibody complexes, treatment and diagnosis of cancer, tetraazacyclododecane compounds | THE DOW CHEMICAL COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0353450-B1 | Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates | DOW CHEMICAL CO (US) | 1995-03-29 | — | — | EP | disclosed |
| EP-0420942-A1 | MACROCYCLIC BIFUNCTIONAL CHELANTS, COMPLEXES THEREOF AND THEIR ANTIBODY CONJUGATES | THE DOW CHEMICAL COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |
| EP-0353450-A1 | Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates | THE DOW CHEMICAL COMPANY (US) | 1990-02-07 | — | — | EP | disclosed |
| WO-1989012631-A1 | MACROCYCLIC BIFUNCTIONAL CHELANTS, COMPLEXES THEREOF AND THEIR ANTIBODY CONJUGATES | THE DOW CHEMICAL COMPANY (US) | 1989-12-28 | — | — | WO | disclosed |