Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2345535 | 0.91 | KMT2A (0.60) | LMNAALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8718675 | 0.86 | MAPT (0.59) | LMNAALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8717326 | 0.85 | P2RX4 (0.63) | LMNAALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL13228922 | 0.82 | VDR (0.57) | LMNAALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8717949 | 0.81 | ALDH1A1 (0.70) | LMNAALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL30616069 | 0.78 | CYP19A1 (0.73) | LMNAALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL29093702 | 0.78 | CYP19A1 (0.73) | LMNAALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL23421206 | 0.78 | LMNA (0.50) | LMNAALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8713413 | 0.77 | ALDH1A1 (0.53) | LMNAALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL96143 | 0.75 | MEN1 (0.56) | LMNAALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843660-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1998-05-27 | — | — | EP | disclosed |
| US-5696148-A | POTENT ANTAGONIST OF METABOTROPIC GLUTAMATE RECEPTORS; TREATING EPILEPSY, PARKINSON'S DISEASE, HUNTINGTON'S DISEASE, BRAIN DISORDER AND ALZHEIMER'S DISEASE | NOVO NORDISK A/S (DK) | 1997-12-09 | — | — | US | disclosed |
| WO-1997005109-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-02-13 | — | — | WO | disclosed |