Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 17/20 | 0.42 |
| ▸ | TSHR | P16473 | 12/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 9/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL62838 | 0.82 | CYP3A4 (0.47) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL52055 | 0.82 | CTSS (0.46) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL52478 | 0.78 | CYP3A4 (0.37) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL8267044 | 0.70 | CYP3A4 (0.52) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL4633248 | 0.69 | PLAU (0.54) | F2PLGPLAUPLAT | |
| SCHEMBL16492790 | 0.67 | ATM (0.52) | F2PLGPLAUPLAT | |
| SCHEMBL16095880 | 0.67 | CTRB1 (0.51) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL26663243 | 0.67 | CYP3A4 (0.51) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL26932299 | 0.66 | CYP3A4 (0.48) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL1551802 | 0.66 | CYP3A4 (0.47) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129398-B2 | HIV integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-06 | — | — | US | disclosed |
| US-20090253677-A1 | HIV Integrase Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253677-A1 | HIV Integrase Inhibitors | DNTT, POLB, UNG | CYP3A4 319/4885TSHR 4845/4885ALDH1A1 539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.