Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 4/20 | 0.54 |
| ▸ | F2 | P00734 | 3/20 | 0.54 |
| ▸ | PLG | P00747 | 3/20 | 0.54 |
| ▸ | PLAT | P00750 | 3/20 | 0.54 |
| ▸ | KLK8 | O60259 | 2/20 | 0.54 |
| ▸ | F10 | P00742 | 2/20 | 0.54 |
| ▸ | KLK4 | Q9Y5K2 | 2/20 | 0.54 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.54 |
| ▸ | KLK1 | P06870 | 1/20 | 0.51 |
| ▸ | KLK2 | P20151 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16492790 | 0.80 | ATM (0.52) | PLAUF2PLGPLATKLK8 | |
| SCHEMBL6140023 | 0.80 | ATM (0.61) | CTRB1CA12CA1CA2CA9 | |
| SCHEMBL11548100 | 0.80 | CTRB1 (0.57) | CTRB1CA12CA1CA2CA9 | |
| SCHEMBL28969071 | 0.78 | PPARA (0.55) | CTSKTACR1 | |
| SCHEMBL28969068 | 0.78 | PPARA (0.55) | CTSKTACR1 | |
| SCHEMBL10953605 | 0.78 | CTRB1 (0.64) | PLAUF2PLATCTRB1CA12 | |
| SCHEMBL14625712 | 0.78 | CTRB1 (0.64) | PLAUF2PLATCTRB1CA12 | |
| Hydrochloric Acid SCHEMBL5741994 | 0.78 | ATM (0.59) | CTRB1CA12CA1CA2CA9 | |
| SCHEMBL1763734 | 0.78 | LMNA (0.57) | PLAUCA12CA1CA2CA9 | |
| SCHEMBL5771343 | 0.77 | ATM (0.52) | PLAUF2PLGPLATKLK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928857-A1 | METHOD FOR PREPARING (3-CHLORO-4-FLUOROPHENYL)-(4-FLUORO-4-{[(5METHYL-PYRIMIDIN-2-YLMETHYL)-AMINO]-METHYL}-PIPERIDIN-1-YL)-METHANONE AND NOVEL INTERMEDIATE PYRIMIDINE DERIVATIVES | PIERRE FABRE MEDICAMENT (FR) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007039499-A1 | METHOD FOR PREPARING (3-CHLORO-4-FLUOROPHENYL)-(4-FLUORO-4-{[(5METHYL-PYRIMIDIN-2-YLMETHYL)-AMINO]-METHYL}-PIPERIDIN-1-YL)-METHANONE AND NOVEL INTERMEDIATE PYRIMIDINE DERIVATIVES | PIERRE FABRE MEDICAMENT (FR) | 2007-04-12 | — | — | WO | disclosed |