Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8716792 | 0.84 | ADRB2 (0.48) | HRH3SLC6A3SLC6A2SLC6A4TSHR | |
| SCHEMBL8717059 | 0.83 | CYP2D6 (0.53) | SLC6A3TSHRALDH1A1CHRM2CHRM1 | |
| SCHEMBL23733409 | 0.77 | HRH3 (0.41) | HRH3SLC6A3SLC6A2SLC6A4TSHR | |
| SCHEMBL16270668 | 0.76 | CHRM2 (0.54) | HRH3SLC6A3SLC6A2SLC6A4TSHR | |
| SCHEMBL2735673 | 0.76 | CHRM2 (0.54) | HRH3SLC6A3SLC6A2SLC6A4TSHR | |
| SCHEMBL9491375 | 0.76 | SLC6A3 (0.50) | SLC6A3SLC6A2SLC6A4ALDH1A1SMN1; SMN2 | |
| SCHEMBL8717426 | 0.76 | DPP4 (0.40) | TSHRSMN1; SMN2OPRM1OPRD1OPRK1 | |
| SCHEMBL2491857 | 0.74 | OPRM1 (0.51) | HRH3SLC6A3SLC6A2SLC6A4TSHR | |
| SCHEMBL31046804 | 0.72 | CYP2D6 (0.54) | HRH3SLC6A3SLC6A2SLC6A4TSHR | |
| SCHEMBL13699289 | 0.71 | CHRNA7 (0.42) | ALDH1A1TDP1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569802-B1 | Arylacetamides | MERCK PATENT GMBH (DE) | 1998-07-15 | — | — | EP | disclosed |
| EP-0569802-A1 | Arylacetamides | MERCK PATENT GmbH (DE) | 1993-11-18 | — | — | EP | disclosed |