Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 2/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720323 | 0.84 | HRH3 (0.42) | ADRB2SLC6A3SLC6A4CYP2D6CHRM2 | |
| SCHEMBL8717059 | 0.81 | CYP2D6 (0.53) | SLC6A3CYP2D6CHRM2CHRM1ADRA2A | |
| SCHEMBL9491375 | 0.81 | SLC6A3 (0.50) | SLC6A3SLC6A4SLC6A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL8719795 | 0.77 | DPP7 (0.43) | ADRB2OPRM1DPP7DPP4 | |
| SCHEMBL22206739 | 0.76 | CHRM2 (0.57) | ADRB2SLC6A3SLC6A4CYP2D6CHRM2 | |
| SCHEMBL22206767 | 0.76 | CHRM2 (0.57) | ADRB2SLC6A3SLC6A4CYP2D6CHRM2 | |
| SCHEMBL16757326 | 0.71 | CYP2D6 (0.66) | SLC6A3SLC6A4CYP2D6CHRM2CHRM1 | |
| SCHEMBL11949354 | 0.71 | ADRB2 (0.62) | ADRB2SLC6A3SLC6A4SLC6A2LMNA | |
| SCHEMBL6789003 | 0.70 | TP53 (0.48) | SLC6A3SLC6A4CYP2D6CHRM2CHRM1 | |
| SCHEMBL16461973 | 0.69 | RPS6KB1 (0.50) | CYP2D6CYP3A4LMNAKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569802-B1 | Arylacetamides | MERCK PATENT GMBH (DE) | 1998-07-15 | — | — | EP | disclosed |
| EP-0569802-A1 | Arylacetamides | MERCK PATENT GmbH (DE) | 1993-11-18 | — | — | EP | disclosed |