Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.38 |
| ▸ | GLRB | P48167 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 5/20 | 0.36 |
| ▸ | EDNRB | P24530 | 2/20 | 0.35 |
| ▸ | EDNRA | P25101 | 2/20 | 0.35 |
| ▸ | LIPC | P11150 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 4/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720353 | 0.78 | CFTR (0.47) | CFTRGLRA3GLRBLTA4HEDNRB | |
| SCHEMBL3349057 | 0.69 | GLRA3 (0.60) | GLRA3GLRBLTA4HCA2CA1 | |
| SCHEMBL8566288 | 0.69 | EDNRB (0.44) | EDNRBEDNRALIPCLIPG | |
| SCHEMBL5063409 | 0.68 | TRPM4 (0.50) | CFTRGLRA3GLRBLTA4HTRPM4 | |
| SCHEMBL23292530 | 0.66 | GLRA3 (0.50) | CFTRGLRA3GLRBLTA4HTRPM4 | |
| SCHEMBL8348277 | 0.66 | CFTR (0.58) | CFTRGLRA3GLRBHDAC4CYP46A1 | |
| SCHEMBL18118210 | 0.65 | CA2 (0.54) | LTA4HCA2CA1CA9CA12 | |
| SCHEMBL305696 | 0.65 | CFTR (0.53) | CFTRGLRA3GLRBALDH1A1KDM4E | |
| SCHEMBL16463175 | 0.64 | CYP46A1 (0.58) | CFTRGLRA3GLRBCYP46A1ALDH1A1 | |
| SCHEMBL28732679 | 0.64 | CA2 (0.47) | CA2CA1CA9CA5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827869-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-10-27 | — | — | US | disclosed |