Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | EDNRB | P24530 | 6/20 | 0.42 |
| ▸ | EDNRA | P25101 | 6/20 | 0.42 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.41 |
| ▸ | GLRB | P48167 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | LIPC | P11150 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | IL2 | P60568 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720324 | 0.78 | CFTR (0.40) | CFTREDNRBEDNRAGLRA3GLRB | |
| SCHEMBL8566288 | 0.72 | EDNRB (0.44) | EDNRBEDNRALIPCLIPG | |
| SCHEMBL3349057 | 0.70 | GLRA3 (0.60) | GLRA3GLRBCA2CA1CA9 | |
| SCHEMBL23292530 | 0.69 | GLRA3 (0.50) | CFTRGLRA3GLRBACLYLTA4H | |
| SCHEMBL8348277 | 0.69 | CFTR (0.58) | CFTRGLRA3GLRBHDAC4CYP46A1 | |
| SCHEMBL5063409 | 0.69 | TRPM4 (0.50) | CFTRGLRA3GLRBACLYHDAC4 | |
| SCHEMBL16463175 | 0.67 | CYP46A1 (0.58) | CFTRGLRA3GLRBCYP46A1 | |
| SCHEMBL6986037 | 0.67 | EDNRB (0.56) | EDNRBEDNRAHDAC4FAAHEPHX2 | |
| SCHEMBL15896819 | 0.66 | GLRA3 (0.56) | CFTRGLRA3GLRBHDAC4LTA4H | |
| SCHEMBL18118210 | 0.66 | CA2 (0.54) | CA2CA1CA9LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827869-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-10-27 | — | — | US | disclosed |