Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 9/20 | 0.44 |
| ▸ | EDNRA | P25101 | 9/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 5/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | LIPC | P11150 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8568213 | 0.72 | EDNRA (0.42) | EDNRBEDNRA | |
| SCHEMBL8720353 | 0.72 | CFTR (0.47) | EDNRBEDNRALIPCLIPG | |
| SCHEMBL8720324 | 0.69 | CFTR (0.40) | EDNRBEDNRALIPCLIPG | |
| SCHEMBL18118210 | 0.68 | CA2 (0.54) | — | |
| SCHEMBL14600782 | 0.68 | ADRA1D (0.46) | EDNRBEDNRAGLO1CKS1BSKP2 | |
| SCHEMBL8572342 | 0.68 | EDNRA (0.67) | EDNRBEDNRA | |
| SCHEMBL7506367 | 0.68 | HPGD (0.37) | EDNRBEDNRAGLO1CKS1BSKP2 | |
| SCHEMBL6986037 | 0.67 | EDNRB (0.56) | EDNRBEDNRA | |
| SCHEMBL7408121 | 0.66 | HPGDS (0.44) | EDNRBEDNRA | |
| SCHEMBL8591966 | 0.66 | LTA4H (0.47) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |
| US-5827869-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-10-27 | — | — | US | disclosed |