SCHEMBL8720535

SCHEMBL8720535

NC(=O)Nc1nccc(Oc2cccc(C(F)(F)F)c2)n1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 5/20 0.59
BRAF P15056 2/20 0.59
MAPK14 Q16539 2/20 0.59
TNNI3K Q59H18 2/20 0.59
MAPT P10636 3/20 0.56
RET P07949 1/20 0.52
PDGFRB P09619 1/20 0.52
KIT P10721 1/20 0.52
FLT1 P17948 1/20 0.52
FLT4 P35916 1/20 0.52
GAA P10253 3/20 0.50
KDM4E B2RXH2 3/20 0.49
ALDH1A1 P00352 2/20 0.49
NR3C2 P08235 1/20 0.49
RAB9A P51151 1/20 0.47
L3MBTL1 Q9Y468 3/20 0.47
MAPK1 P28482 2/20 0.47
NPSR1 Q6W5P4 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
P2RY1 P47900 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8721009 0.83 MAPT (0.55) KDRBRAFMAPK14TNNI3KMAPT
SCHEMBL8722722 0.80 NR3C2 (0.54) MAPTGAAKDM4EALDH1A1NR3C2
SCHEMBL8721027 0.79 KMO (0.60) KDRBRAFMAPK14TNNI3KMAPT
SCHEMBL8723629 0.77 MAPT (0.52) KDRBRAFMAPK14TNNI3KMAPT
SCHEMBL8569584 0.76 MAPT (0.73) MAPTGAAKDM4EALDH1A1L3MBTL1
SCHEMBL8723508 0.76 GAA (0.58) KDRBRAFMAPK14TNNI3KMAPT
SCHEMBL3841693 0.75 MAPT (0.75) KDRBRAFMAPK14TNNI3KMAPT
SCHEMBL11581513 0.75 KIF11 (0.64) KDRBRAFMAPK14TNNI3KMAPT
SCHEMBL8773158 0.74 MAPT (0.65) MAPTGAAKDM4EALDH1A1L3MBTL1
SCHEMBL29607042 0.74 MAPT (0.65) MAPTGAAKDM4EALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0700391-B1 HERBICIDAL COMPOUNDS SHELL INT RESEARCH (NL) 1998-10-21 EP disclosed
US-5759956-A PYRAZINE CARBOXAMIDE DERIVATIVES AMERICAN CYANAMID COMPANY (US) 1998-06-02 US disclosed
EP-0700391-A1 HERBICIDAL COMPOUNDS SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1996-03-13 EP disclosed
WO-1994027974-A1 HERBICIDAL COMPOUNDS SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 1994-12-08 WO disclosed