Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | P2RY1 | P47900 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8722720 | 0.82 | MAPT (0.49) | MAPTP2RY1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL8720535 | 0.80 | KDR (0.59) | NR3C2MAPTP2RY1KDM4EGAA | |
| SCHEMBL8721822 | 0.78 | MAPT (0.50) | MAPTP2RY1KDM4EGAAALDH1A1 | |
| SCHEMBL8721823 | 0.75 | P2RY1 (0.57) | MAPTP2RY1KDM4EGAAAURKA | |
| SCHEMBL11581513 | 0.74 | KIF11 (0.64) | MAPTCDK8AURKA | |
| SCHEMBL5029590 | 0.72 | NR3C2 (0.67) | NR3C2GAAALDH1A1L3MBTL1 | |
| SCHEMBL30875900 | 0.72 | NR3C2 (0.67) | NR3C2GAAALDH1A1L3MBTL1 | |
| SCHEMBL8721009 | 0.72 | MAPT (0.55) | MAPTP2RY1KDM4EGAAALDH1A1 | |
| SCHEMBL8724391 | 0.72 | CTSS (0.49) | MAPTP2RY1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL4540871 | 0.70 | NR3C2 (1.00) | NR3C2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5759956-A | PYRAZINE CARBOXAMIDE DERIVATIVES | AMERICAN CYANAMID COMPANY (US) | 1998-06-02 | — | — | US | disclosed |
| EP-0700391-A1 | HERBICIDAL COMPOUNDS | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1996-03-13 | — | — | EP | disclosed |
| WO-1994027974-A1 | HERBICIDAL COMPOUNDS | SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) | 1994-12-08 | — | — | WO | disclosed |