Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | NOS1 | P29475 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8723863 | 0.91 | SLC6A4 (0.41) | NOS3NOS1SLC6A4MAPTPOLB | |
| SCHEMBL8723621 | 0.85 | NOS3 (0.44) | NOS3NOS1SLC6A4MAPTPOLB | |
| SCHEMBL8721897 | 0.84 | NOS3 (0.43) | NOS3NOS1SLC6A4MAPTDRD2 | |
| SCHEMBL8725951 | 0.83 | MAPT (0.49) | NOS3NOS1MAPTPOLB | |
| SCHEMBL7485764 | 0.83 | SLC6A4 (0.63) | NOS3NOS1SLC6A4 | |
| SCHEMBL8721916 | 0.81 | NOS3 (0.47) | NOS3NOS1SLC6A4MAPTPOLB | |
| SCHEMBL8386958 | 0.80 | NOS3 (0.42) | NOS3NOS1SLC6A4MAPTPOLB | |
| SCHEMBL8383229 | 0.79 | SLC6A4 (0.56) | SLC6A4DRD2HTR1A | |
| SCHEMBL8722143 | 0.79 | NOS3 (0.47) | NOS3NOS1SLC6A4MAPTDRD2 | |
| SCHEMBL8386633 | 0.79 | NOS3 (0.41) | NOS3NOS1SLC6A4MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0875513-A1 | Substituted heteroaromatic 5-HT 1F agonists | ELI LILLY AND COMPANY (US) | 1998-11-04 | — | — | EP | disclosed |