Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 5/20 | 0.50 |
| ▸ | KIF11 | P52732 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.37 |
| ▸ | ABAT | P80404 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31083678 | 1.00 | CYP2A6 (0.50) | CYP2A6KIF11ALDH1A1KDM4EPTGS2 | |
| SCHEMBL6860177 | 0.90 | GPR3 (0.54) | CYP2A6KIF11ALDH1A1KDM4ERAB9A | |
| SCHEMBL10018348 | 0.86 | CYP2A6 (0.47) | CYP2A6KIF11ALDH1A1KDM4EPTGS2 | |
| SCHEMBL6689810 | 0.81 | KDM4E (0.60) | CYP2A6KIF11ALDH1A1KDM4ERAB9A | |
| SCHEMBL13242812 | 0.80 | APP (0.41) | CYP2A6KIF11ALDH1A1KDM4ETDP1 | |
| SCHEMBL10970273 | 0.77 | GPR3 (0.54) | CYP2A6KIF11ALDH1A1KDM4ERAB9A | |
| SCHEMBL21298255 | 0.74 | MEN1 (0.40) | CYP2A6ALDH1A1RAB9ATDP1MEN1 | |
| SCHEMBL12581557 | 0.73 | MCL1 (0.41) | CYP2A6KIF11ALDH1A1KDM4ERAB9A | |
| SCHEMBL9537045 | 0.73 | GPR3 (0.44) | CYP2A6KIF11ALDH1A1KDM4ERAB9A | |
| SCHEMBL12683511 | 0.73 | CYP2A6 (0.54) | CYP2A6ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110124556-A1 | Insulin and IGF-1 Receptor Agonists and Antagonists | NOVO NORDISK A/S (DK) | 2011-05-26 | — | — | US | disclosed |
| US-20110124556-A1 | Insulin and IGF-1 Receptor Agonists and Antagonists | NOVO NORDISK A/S (DK) | 2011-05-26 | — | — | US | disclosed |
| US-20090192072-A1 | Insulin and IGF-1 Receptor Agonists and Antagonists | NOVO NORDISK A/S (DK) | 2009-07-30 | — | — | US | disclosed |
| US-20090192072-A1 | Insulin and IGF-1 Receptor Agonists and Antagonists | NOVO NORDISK A/S (DK) | 2009-07-30 | — | — | US | disclosed |
| US-20090053807-A1 | Insulin and IGF-1 Receptor Agonists and Antagonists | NOVO NORDISK A/S (DK) | 2009-02-26 | — | — | US | disclosed |
| US-20090053807-A1 | Insulin and IGF-1 Receptor Agonists and Antagonists | NOVO NORDISK A/S (DK) | 2009-02-26 | — | — | US | disclosed |
| US-20070265189-A1 | INSULIN AND IGF-1 RECEPTOR AGONISTS AND ANTAGONISTS | NOVO NORDISK A/S (DK) | 2007-11-15 | — | — | US | disclosed |
| US-20070265189-A1 | INSULIN AND IGF-1 RECEPTOR AGONISTS AND ANTAGONISTS | NOVO NORDISK A/S (DK) | 2007-11-15 | — | — | US | disclosed |
| US-7173005-B2 | Peptide sequences capable of binding to insulin and/or insulin- like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at | ANTYRA INC. (US) | 2007-02-06 | — | — | US | disclosed |
| US-7173005-B2 | Peptide sequences capable of binding to insulin and/or insulin- like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at | ANTYRA INC. (US) | 2007-02-06 | — | — | US | disclosed |
| US-20070004634-A1 | Insulin and IGF-1 receptor agonists and antagonists | NOVO NORDISK A/S (DK) | 2007-01-04 | — | — | US | disclosed |
| US-20070004634-A1 | Insulin and IGF-1 receptor agonists and antagonists | NOVO NORDISK A/S (DK) | 2007-01-04 | — | — | US | disclosed |
| US-5807974-A | POLYARYLENEVINYLENE RESIN | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 1998-09-15 | — | — | US | disclosed |
| EP-0041675-B1 | 4-HALOGEN-5-(TRICHLOROMETHYL-PHENYL)-OXAZOLE DERIVATIVES, PROCESS FOR PREPARING THEM AND RADIATION-SENSITIVE COMPOSITIONS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-12-11 | — | — | EP | disclosed |
| US-4371607-A | 4-Halogeno-5-(halogenomethyl-phenyl)-oxazole derivatives, a process for the preparation thereof, and radiation-sensitive compositions containing these derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-02-01 | — | — | US | disclosed |
| EP-0041675-A2 | 4-Halogen-5-(trichloromethyl-phenyl)-oxazole derivatives, process for preparing them and radiation-sensitive compositions containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-12-16 | — | — | EP | disclosed |
| US-4017313-A | Photosensitive composition containing a leuco dye, a photosensitizer, an aromatic aldehyde and a secondary or tertiary amine and the use thereof in a direct-print process | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124556-A1 | Insulin and IGF-1 Receptor Agonists and Antagonists | IGF1R, IGFBP1, IGFBP2 | CYP2A6 4747/4885KIF11 3173/4885ALDH1A1 4072/4885 |
| US-20090192072-A1 | Insulin and IGF-1 Receptor Agonists and Antagonists | IGF1R, IGFBP1, IGFBP2 | CYP2A6 4747/4885KIF11 3173/4885ALDH1A1 4072/4885 |
| US-20070265189-A1 | INSULIN AND IGF-1 RECEPTOR AGONISTS AND ANTAGONISTS | IGF1R, IGFBP1, IGFBP2 | CYP2A6 4747/4885KIF11 3173/4885ALDH1A1 4072/4885 |
| US-20070004634-A1 | Insulin and IGF-1 receptor agonists and antagonists | IGF1R, IGFBP1, IGFBP2 | CYP2A6 4775/4885KIF11 3187/4885ALDH1A1 4149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.