Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | ESRRG | P62508 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL515166 | 0.87 | KMT2A (0.48) | ESR1ESR2HPGDTSHRHSD17B10 | |
| SCHEMBL10392048 | 0.81 | MMP13 (0.50) | ESR1ESR2HPGDTSHRHSD17B10 | |
| SCHEMBL10392044 | 0.81 | ESR1 (0.40) | ESR1ESR2CYP3A4HPGDTSHR | |
| SCHEMBL9874462 | 0.79 | MMP13 (0.50) | ESR1ESR2ALDH1A1KMT2ALMNA | |
| SCHEMBL8722675 | 0.79 | ESR1 (0.44) | ESR1ESR2HPGDTSHRHSD17B10 | |
| SCHEMBL10391857 | 0.77 | ESR1 (0.41) | ESR1HPGDTSHRHSD17B10ALDH1A1 | |
| SCHEMBL9773502 | 0.74 | MMP13 (0.38) | HPGDTSHRHSD17B10ALDH1A1KMT2A | |
| SCHEMBL10401778 | 0.71 | DDB1 (0.44) | HSD17B10ALDH1A1KMT2ALMNAMMP13 | |
| SCHEMBL9730839 | 0.71 | MMP13 (0.52) | ALDH1A1KMT2ALMNAMMP13POLB | |
| SCHEMBL9736118 | 0.70 | CA12 (0.56) | CYP3A4HPGDTSHRALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4939251-A | Novel spirolactones | SHELL OIL COMPANY (US) | 1990-07-03 | — | — | US | claimed |
| US-4889907-A | Polymeric polyhyroxy polyether containing 1,6-diazaspiro-[4.4]nonane-2,7-dione units | SHELL OIL COMPANY (US) | 1989-12-26 | — | — | US | claimed |
| EP-0443688-B1 | Spirodilactam-arylsulfone oligomers | SHELL INT RESEARCH (NL) | 1998-05-06 | — | — | EP | disclosed |
| EP-0372656-B1 | Polymers comprising spirolactam units | SHELL INT RESEARCH (NL) | 1995-06-07 | — | — | EP | disclosed |
| EP-0359341-B1 | 1,6-diazaspiro[4,4]nonane-2,7-dione derivatives | SHELL INT RESEARCH (NL) | 1994-02-16 | — | — | EP | disclosed |
| US-5128436-A | Cyclic polyhydroxy polyether oligomers having spirodilactam units | SHELL OIL COMPANY (US) | 1992-07-07 | — | — | US | disclosed |
| US-5095088-A | Cyclic polycarbonate oligomer containing spiro diLactam moieties | SHELL OIL COMPANY (US) | 1992-03-10 | — | — | US | disclosed |
| US-5059674-A | Cured arylcyclobutene ether spirodilactam | SHELL OIL COMPANY (US) | 1991-10-22 | — | — | US | disclosed |
| US-5049640-A | Polyetherketones | SHELL OIL COMPANY (US) | 1991-09-17 | — | — | US | disclosed |
| EP-0443688-A2 | Spirodilactam-arylsulfone oligomers | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1991-08-28 | — | — | EP | disclosed |
| US-5030707-A | Polycarbonate polymer having spirodilactam moieties | SHELL OIL COMPANY (US) | 1991-07-09 | — | — | US | disclosed |
| US-4935489-A | LINEAR ALTERNATING, THERMOPLASTIC POLYETHERS; HIGH GLASS TRANSITION TEMPERATURE; DIMENSIONAL STABILITY | SHELL OIL COMPANY (US) | 1990-06-19 | — | — | US | disclosed |
| EP-0372656-A2 | Polymers comprising spirolactam units | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1990-06-13 | — | — | EP | disclosed |
| US-4921931-A | Thermosetting resin compositions | SHELL OIL COMPANY (US) | 1990-05-01 | — | — | US | disclosed |
| EP-0359341-A2 | 1,6-diazaspiro[4,4]nonane-2,7-dione derivatives | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1990-03-21 | — | — | EP | disclosed |
| US-4910285-A | Polyarylate polymers | SHELL OIL COMPANY (US) | 1990-03-20 | — | — | US | disclosed |
| US-4906725-A | Polycarbonate containing spiro dilactam segment | SHELL OIL COMPANY (US) | 1990-03-06 | — | — | US | disclosed |
| US-4895942-A | Novel epoxy compounds | SHELL OIL COMPANY (US) | 1990-01-23 | — | — | US | disclosed |
| US-4889907-A | Polymeric polyhyroxy polyether containing 1,6-diazaspiro-[4.4]nonane-2,7-dione units | SHELL OIL COMPANY (US) | 1989-12-26 | — | — | US | disclosed |
| US-4847388-A | Polycyclic unsaturated ethers and esters | SHELL OIL COMPANY (US) | 1989-07-11 | — | — | US | disclosed |