Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.46 |
| ▸ | SELE | P16581 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.44 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8721822 | 0.89 | MAPT (0.50) | MAPTKDM4EKMT2AP2RY1ALDH1A1 | |
| SCHEMBL8722722 | 0.82 | NR3C2 (0.54) | MAPTKDM4EP2RY1EGFRALDH1A1 | |
| SCHEMBL8569584 | 0.81 | MAPT (0.73) | MAPTICAM1SELECHEK2KDM4E | |
| SCHEMBL8721823 | 0.80 | P2RY1 (0.57) | MAPTKDM4EKMT2AP2RY1EGFR | |
| SCHEMBL8721009 | 0.78 | MAPT (0.55) | MAPTICAM1SELECHEK2KDM4E | |
| SCHEMBL13728192 | 0.75 | KMO (0.52) | KDM4ESCN9AALDH1A1 | |
| SCHEMBL3844011 | 0.75 | MAPT (0.58) | MAPTICAM1SELECHEK2KDM4E | |
| SCHEMBL9233259 | 0.75 | MAPT (0.49) | MAPTICAM1SELECHEK2KDM4E | |
| SCHEMBL17242347 | 0.74 | SCN9A (0.44) | KDM4ESCN9AF10 | |
| SCHEMBL8724391 | 0.74 | CTSS (0.49) | MAPTKDM4EKMT2AP2RY1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5759956-A | PYRAZINE CARBOXAMIDE DERIVATIVES | AMERICAN CYANAMID COMPANY (US) | 1998-06-02 | — | — | US | disclosed |
| EP-0700391-A1 | HERBICIDAL COMPOUNDS | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1996-03-13 | — | — | EP | disclosed |
| WO-1994027974-A1 | HERBICIDAL COMPOUNDS | SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) | 1994-12-08 | — | — | WO | disclosed |