Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | DRD4 | P21917 | 1/20 | 0.72 |
| ▸ | HTR1A | P08908 | 6/20 | 0.72 |
| ▸ | HTR1D | P28221 | 6/20 | 0.72 |
| ▸ | HTR1B | P28222 | 6/20 | 0.72 |
| ▸ | HTR2C | P28335 | 4/20 | 0.72 |
| ▸ | HTR6 | P50406 | 3/20 | 0.72 |
| ▸ | HTR2A | P28223 | 2/20 | 0.72 |
| ▸ | HTR7 | P34969 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | TSHR | P16473 | 4/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720632 | 0.86 | MEN1 (0.69) | MAPTDRD4HTR1AHTR7ALDH1A1 | |
| SCHEMBL4005507 | 0.84 | DRD4 (1.00) | MAPTDRD4ALDH1A1TSHRKDM4E | |
| SCHEMBL8759779 | 0.84 | HTR1A (1.00) | MAPTHTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL18658203 | 0.81 | TSHR (0.76) | MAPTDRD4HTR1AHTR7ALDH1A1 | |
| SCHEMBL14734295 | 0.80 | HTR1D (0.62) | MAPTHTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8720335 | 0.80 | HTR1A (0.61) | DRD4HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL11117410 | 0.80 | KDM4E (0.66) | MAPTDRD4HTR1AALDH1A1TSHR | |
| SCHEMBL4032615 | 0.80 | ALDH1A1 (0.65) | MAPTDRD4HTR2CHTR2AALDH1A1 | |
| SCHEMBL6354568 | 0.80 | HTR1D (0.57) | HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL14207957 | 0.79 | MAPT (0.66) | MAPTDRD4ALDH1A1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998042692-A1 | PIPERAZINES DERIVED FROM CYCLIC AMINES, PREPARATION AND APPLICATION THEREOF AS MEDICINES | PIERRE FABRE MEDICAMENT (FR) | 1998-10-01 | — | — | WO | disclosed |