Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 5/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.43 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14497664 | 0.83 | NPSR1 (0.59) | KMT2AMEN1FOLH1NPSR1L3MBTL1 | |
| SCHEMBL7900436 | 0.83 | KMT2A (0.69) | KMT2AMEN1FOLH1NPSR1L3MBTL1 | |
| SCHEMBL8723896 | 0.83 | KMT2A (0.69) | KMT2AMEN1FOLH1NPSR1L3MBTL1 | |
| SCHEMBL10692268 | 0.79 | NR3C1 (0.47) | KMT2AMEN1NPSR1L3MBTL1CNR2 | |
| SCHEMBL29071696 | 0.77 | NAALAD2 (0.68) | KMT2AMEN1FOLH1NAALAD2TMPRSS15 | |
| SCHEMBL29071699 | 0.77 | NAALAD2 (0.68) | KMT2AMEN1FOLH1NAALAD2TMPRSS15 | |
| SCHEMBL6567538 | 0.77 | NAALAD2 (0.66) | KMT2AMEN1FOLH1NAALAD2CNR2 | |
| SCHEMBL6567542 | 0.77 | NAALAD2 (0.66) | KMT2AMEN1FOLH1NAALAD2CNR2 | |
| SCHEMBL27694707 | 0.77 | NAALAD2 (0.66) | KMT2AMEN1FOLH1NAALAD2CNR2 | |
| SCHEMBL4923938 | 0.76 | ALDH1A1 (0.60) | KMT2AMEN1FOLH1NAALAD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0651740-B1 | AMINO ACID LINKED NITROGEN MUSTARD DERIVATIVES AND THEIR USE AS PRODRUGS IN THE TREATMENT OF TUMOURS | ZENECA LTD (GB) | 1998-10-21 | — | — | EP | claimed |
| EP-0651740-B1 | AMINO ACID LINKED NITROGEN MUSTARD DERIVATIVES AND THEIR USE AS PRODRUGS IN THE TREATMENT OF TUMOURS | ZENECA LTD (GB) | 1998-10-21 | — | — | EP | disclosed |