SCHEMBL8723259

SCHEMBL8723259

O=c1[nH]ncn1-c1ccc(F)cc1F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.42
RAB9A P51151 1/20 0.42
HTT P42858 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.40
HCAR1 Q9BXC0 2/20 0.38
GLA P06280 1/20 0.38
MAPK13 O15264 2/20 0.36
MAPK12 P53778 2/20 0.36
MAPK11 Q15759 2/20 0.36
MAPK14 Q16539 2/20 0.36
AKR1B1 P15121 1/20 0.36
OPRM1 P35372 1/20 0.35
CYP17A1 P05093 1/20 0.35
AKT1 P31749 1/20 0.35
ATM Q13315 1/20 0.34
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA4 P22748 1/20 0.34
CA6 P23280 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30947201 0.83 RAB9A (0.41) TDP1RAB9AHTTHCAR1AKR1B1
SCHEMBL16196993 0.83 RAB9A (0.41) TDP1RAB9AHTTHCAR1AKR1B1
SCHEMBL23564714 0.83 HCAR1 (0.55) RAB9AHTTHCAR1MAPK13MAPK12
SCHEMBL21385220 0.80 HTT (0.40) TDP1RAB9AHTTAKR1B1
SCHEMBL8718617 0.74 HTT (0.54) TDP1RAB9AHTTHCAR1CA12
SCHEMBL23931446 0.72 HTT (0.65) HTTL3MBTL1
SCHEMBL8536677 0.72 L3MBTL1 (0.37) L3MBTL1GLAMAPK13MAPK12MAPK11
SCHEMBL16303987 0.71 L3MBTL1 (0.42) RAB9AL3MBTL1GLAMAPK13MAPK12
SCHEMBL21384879 0.70 HTT (0.54) TDP1RAB9AHTT
SCHEMBL21434861 0.70 HTT (0.50) TDP1RAB9AHTTHCAR1ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0567982-B1 Azole compounds, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1998-07-01 EP disclosed
US-5466820-A Fungicides TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-11-14 US disclosed
US-5371101-A Fungicides TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-12-06 US disclosed
EP-0567982-A1 Azole compounds, their production and use Takeda Chemical Industries, Ltd. (JP) 1993-11-03 EP disclosed