Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8725786 | 0.88 | L3MBTL1 (0.53) | L3MBTL1KMT2ARAB9ANPC1RECQL | |
| SCHEMBL8721558 | 0.88 | L3MBTL1 (0.53) | L3MBTL1KMT2ARAB9ANPC1RECQL | |
| SCHEMBL8722487 | 0.88 | L3MBTL1 (0.53) | L3MBTL1KMT2ARAB9ANPC1RECQL | |
| Hydrochloric Acid SCHEMBL8723501 | 0.82 | L3MBTL1 (0.48) | L3MBTL1KMT2ARAB9ANPC1RECQL | |
| SCHEMBL8725784 | 0.79 | L3MBTL1 (0.54) | L3MBTL1KMT2ARAB9ANPC1RECQL | |
| SCHEMBL8721554 | 0.79 | L3MBTL1 (0.54) | L3MBTL1KMT2ARAB9ANPC1RECQL | |
| SCHEMBL8722484 | 0.79 | L3MBTL1 (0.54) | L3MBTL1KMT2ARAB9ANPC1RECQL | |
| SCHEMBL8721566 | 0.76 | L3MBTL1 (0.44) | L3MBTL1KMT2ARAB9ANPC1RECQL | |
| SCHEMBL8581954 | 0.75 | NPC1 (0.72) | L3MBTL1KMT2ARAB9ANPC1RECQL | |
| SCHEMBL1123538 | 0.75 | NPC1 (0.72) | L3MBTL1KMT2ARAB9ANPC1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5800624-A | LIPOPHILIC POLYMER, HYDROPHOBIC PLASTICIZER, QUATERNARY AMMONIUM OR PHOSPHONIUM CARRIER | UNIVERSITY OF NOTRE DAME (US) | 1998-09-01 | — | — | US | disclosed |