SCHEMBL8723696

SCHEMBL8723696

CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)CC(=O)NCCCCCCCCCCN

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A5 Q9Y345 2/20 0.55
CASP2 P42575 1/20 0.50
GNAI3 P08754 1/20 0.50
GNAO1 P09471 1/20 0.50
GNAI1 P63096 1/20 0.50
KDM4A O75164 1/20 0.48
HIF1A Q16665 1/20 0.48
TET2 Q6N021 1/20 0.48
DOHH Q9BU89 1/20 0.48
NAAA Q02083 1/20 0.47
PAOX Q6QHF9 2/20 0.47
DNM1 Q05193 2/20 0.46
EPHX1 P07099 5/20 0.46
SIRT6 Q8N6T7 1/20 0.46
SIRT1 Q96EB6 1/20 0.46
RRM1 P23921 1/20 0.45
KDM4E B2RXH2 1/20 0.45
LMNA P02545 1/20 0.45
GAA P10253 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19040774 0.92 CASP2 (0.58) CASP2NAAADNM1EPHX1FAAH
SCHEMBL1037232 0.91 SLC6A5 (0.47) SLC6A5CASP2GNAI3GNAO1GNAI1
SCHEMBL3394523 0.91 SLC6A5 (0.47) SLC6A5CASP2GNAI3GNAO1GNAI1
SCHEMBL23576154 0.89 CASP2 (0.55) CASP2NAAADNM1EPHX1FAAH
SCHEMBL9288287 0.89 CASP2 (0.55) CASP2NAAADNM1EPHX1FAAH
SCHEMBL9285562 0.89 CASP2 (0.55) CASP2NAAADNM1EPHX1FAAH
SCHEMBL20589913 0.89 CASP2 (0.55) CASP2NAAADNM1EPHX1FAAH
SCHEMBL2028359 0.88 CASP2 (0.50) SLC6A5CASP2GNAI3GNAO1GNAI1
SCHEMBL23606518 0.88 DNM1 (0.44) SLC6A5CASP2GNAI3GNAO1GNAI1
SCHEMBL9394285 0.85 PAOX (0.50) SLC6A5GNAI3GNAO1GNAI1KDM4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5730956-A DTPA di-alkyl monoamides for x-ray and MRI SCHERING AKTIENGESELLSCHAFT (DE) 1998-03-24 US disclosed
EP-0810990-A1 SUBSTITUTED DTPA MONOAMIDES OF CENTRAL CARBOXYLIC ACIDS AND METAL COMPLEXES THEREOF, PHARMACEUTICALS CONTAINING THESE COMPLEXES, DIAGNOSTIC AND THERAPEUTIC USES THEREOF AND METHODS FOR PREPARING THE COMPLEXES AND PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 1997-12-10 EP disclosed
US-5679852-A Process for the production of DTPA-monoamides of the central carboxylic acid and their use as pharmaceutical agents SCHERING AKTIENGESELLSCHAFT (DE) 1997-10-21 US disclosed
US-5676923-A SOLUBLE, STABLE, ORGAN-SPECIFIC NUCLEAR MAGNETIC RESONANCE CONTRAST AGENT SCHERING AKTIENGESELLSCHAFT (DE) 1997-10-14 US disclosed
WO-1996026182-A1 SUBSTITUTED DTPA MONOAMIDES OF CENTRAL CARBOXYLIC ACIDS AND METAL COMPLEXES THEREOF, PHARMACEUTICALS CONTAINING THESE COMPLEXES, DIAGNOSTIC AND THERAPEUTIC USES THEREOF AND METHODS FOR PREPARING THE COMPLEXES AND PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 1996-08-29 WO disclosed