Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.72 |
| ▸ | RAB9A | P51151 | 4/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.72 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.53 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.52 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3224949 | 0.85 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2EPHX2KMT2A | |
| SCHEMBL13495002 | 0.85 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2EPHX2KMT2A | |
| SCHEMBL21523088 | 0.84 | EPHX2 (0.65) | NPC1RAB9ASMN1; SMN2EPHX2CYP2C9 | |
| SCHEMBL21523087 | 0.84 | EPHX2 (0.65) | NPC1RAB9ASMN1; SMN2EPHX2CYP2C9 | |
| SCHEMBL1568754 | 0.84 | RAB9A (0.79) | NPC1RAB9ASMN1; SMN2EPHX2CYP2C9 | |
| SCHEMBL8482617 | 0.81 | EPHX2 (0.64) | NPC1RAB9ASMN1; SMN2EPHX2CYP2C9 | |
| SCHEMBL28115750 | 0.81 | KMT2A (0.69) | NPC1RAB9ASMN1; SMN2EPHX2CYP2C9 | |
| SCHEMBL8722504 | 0.81 | KMT2A (0.69) | NPC1RAB9ASMN1; SMN2EPHX2CYP2C9 | |
| SCHEMBL5947875 | 0.80 | EPHX2 (1.00) | NPC1RAB9ASMN1; SMN2EPHX2CYP2C9 | |
| SCHEMBL28309218 | 0.79 | THRB (0.71) | NPC1RAB9ASMN1; SMN2EPHX2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0335545-B2 | Pharmaceutical formulations for parenteral use | UNIV FLORIDA (US) | 1998-09-23 | — | — | EP | disclosed |
| EP-0327766-B1 | Redox systems for brain-targeted drug delivery | UNIV FLORIDA (US) | 1998-04-08 | — | — | EP | disclosed |
| US-5024998-A | Administering in aqueous solution with cyclodextrin derivative | UNIVERSITY OF FLORIDA (US) | 1991-06-18 | — | — | US | disclosed |
| US-5017566-A | Redox systems for brain-targeted drug delivery | UNIVERSITY OF FLORIDA (US) | 1991-05-21 | — | — | US | disclosed |
| US-5002935-A | Inclusion Complexing Hydroxypropylcyclodextrin with a Dihydropyridine-substituted Drug | UNIVERSITY OF FLORIDA (US) | 1991-03-26 | — | — | US | disclosed |
| US-4983586-A | Decreasing precipitation at injection site or in lungs or other organs by combining with hydroxypropyl-beta-cyclodextrin | UNIVERSITY OF FLORIDA (US) | 1991-01-08 | — | — | US | disclosed |
| EP-0335545-A2 | Pharmaceutical formulations for parenteral use | UNIVERSITY OF FLORIDA (US) | 1989-10-04 | — | — | EP | disclosed |
| EP-0327766-A2 | Redox systems for brain-targeted drug delivery | UNIVERSITY OF FLORIDA (US) | 1989-08-16 | — | — | EP | disclosed |