Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GRM7 | Q14831 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7432153 | 0.85 | PRMT5 (0.50) | MTNR1AMTNR1BDPP4PRMT5GRIN2B | |
| SCHEMBL13981017 | 0.82 | MTNR1A (0.51) | MTNR1AMTNR1BDPP4PRMT5GRIN2B | |
| SCHEMBL6262070 | 0.81 | EPHX2 (0.47) | MTNR1AMTNR1BDPP4PRMT5GRIN2B | |
| SCHEMBL7334700 | 0.81 | MTNR1A (0.47) | MTNR1AMTNR1BDPP4PRMT5GRIN2B | |
| Hydrochloric Acid SCHEMBL7334726 | 0.80 | MTNR1A (0.46) | MTNR1AMTNR1BDPP4PRMT5GRIN2B | |
| Hydrochloric Acid SCHEMBL10493763 | 0.80 | EPHX2 (0.46) | MTNR1AMTNR1BDPP4PRMT5GRIN2B | |
| SCHEMBL10204444 | 0.79 | MTNR1A (0.53) | MTNR1AMTNR1BDPP4PRMT5GRIN2B | |
| SCHEMBL29434614 | 0.76 | GRIN2B (0.53) | MTNR1AMTNR1BDPP4PRMT5GRIN2B | |
| SCHEMBL255286 | 0.76 | GRIN2B (0.53) | MTNR1AMTNR1BDPP4PRMT5GRIN2B | |
| SCHEMBL7301279 | 0.76 | ALDH1A1 (0.50) | GRIN2BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834431-A | Des-Arg9 -BK antagonists | CORTECH, INC. (US) | 1998-11-10 | — | — | US | disclosed |
| US-5648336-A | POLYPEPTIDE AND INDANEGLYCINE DERIVATIVES AS ANTIINFLAMMATORY AND HYPOTENSIVES | UNIVERSITY OF COLORADO (US) | 1997-07-15 | — | — | US | disclosed |
| WO-1997009346-A1 | DES-ARG9-BK ANTAGONISTS | CORTECH, INC. (US) | 1997-03-13 | — | — | WO | disclosed |
| WO-1996016081-A1 | BRADYKININ ANTAGONIST PEPTIDES CONTAINING INDANE-SUBSTITUTED AMINO ACIDS | UNIVERSITY TECHNOLOGY CORPORATION (US) | 1996-05-30 | — | — | WO | disclosed |