Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 10/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 10/20 | 0.41 |
| ▸ | PRMT8 | Q9NR22 | 3/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.34 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5789303 | 0.82 | CARM1 (0.34) | CARM1PRMT6PRMT8PRMT1HRH3 | |
| SCHEMBL1111914 | 0.80 | PABPC1 (0.47) | CARM1PRMT6PRMT8PRMT1PABPC1 | |
| SCHEMBL8728946 | 0.79 | CARM1 (0.37) | CARM1PRMT6PRMT8PRMT1PABPC1 | |
| SCHEMBL2280536 | 0.78 | CARM1 (0.41) | CARM1PRMT6PRMT8PRMT1HRH3 | |
| SCHEMBL14173452 | 0.78 | ALOX15 (0.50) | CARM1PRMT6PRMT8PRMT1HRH3 | |
| SCHEMBL3412663 | 0.78 | KDM1A (0.44) | CARM1PRMT6PRMT8PRMT1HRH3 | |
| SCHEMBL23936696 | 0.78 | CARM1 (0.37) | CARM1PRMT6PRMT8PRMT1HRH3 | |
| SCHEMBL1268695 | 0.77 | GNAO1 (0.51) | CARM1PRMT6PRMT8PRMT1HRH3 | |
| SCHEMBL2250676 | 0.75 | CARM1 (0.38) | CARM1PRMT6PRMT8PRMT1HRH3 | |
| SCHEMBL963156 | 0.75 | KDM1A (0.49) | CARM1PRMT6PRMT8PRMT1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624584-B1 | Piperazine derivatives useful as calmodulin inhibitors | DAIICHI SEIYAKU CO (JP) | 1998-08-19 | — | — | EP | disclosed |
| US-5681954-A | HAS CALMODULIN INHIBITORY ACTIVITY; USEFUL IN TREATING DISEASES OF THE CIRCULATORY ORGANS OR IN CEREBRAL REGION | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1997-10-28 | — | — | US | disclosed |
| EP-0624584-A1 | Piperazine derivatives useful as calmodolin inhibitors | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1994-11-17 | — | — | EP | disclosed |