Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 7/20 | 0.52 |
| ▸ | JUN | P05412 | 4/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.52 |
| ▸ | RELA | Q04206 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 8/20 | 0.33 |
| ▸ | ATF1 | P18846 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8889739 | 0.91 | MAPT (0.48) | NFKB1JUNNFKB2RELAKDM4E | |
| SCHEMBL8721324 | 0.88 | KDM4E (0.56) | NFKB1JUNNFKB2RELAKDM4E | |
| SCHEMBL8888457 | 0.85 | CNR2 (0.39) | NFKB1JUNNFKB2RELAKDM4E | |
| SCHEMBL8721355 | 0.83 | MAPT (0.41) | NFKB1JUNNFKB2RELAKDM4E | |
| SCHEMBL8725201 | 0.81 | KDM4E (0.47) | NFKB1JUNNFKB2RELAKDM4E | |
| SCHEMBL8722111 | 0.78 | NFKB1 (0.60) | NFKB1JUNNFKB2RELAKDM4E | |
| SCHEMBL8721300 | 0.74 | RAB9A (0.52) | NFKB1JUNNFKB2RELAKDM4E | |
| SCHEMBL8726399 | 0.72 | RAB9A (0.42) | NFKB1JUNNFKB2RELAKDM4E | |
| SCHEMBL8725171 | 0.72 | NFKB1 (0.52) | NFKB1JUNNFKB2RELAKDM4E | |
| SCHEMBL8724454 | 0.70 | HSP90AA1 (0.55) | NFKB1JUNNFKB2RELAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997009325-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1997-03-13 | — | — | WO | disclosed |