Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8725290 | 0.80 | POLB (0.41) | IDO1TDO2FBP1HTTEGFR | |
| SCHEMBL8725864 | 0.75 | NQO1 (0.54) | HTTLMNAPOLBALDH1A1MAPT | |
| SCHEMBL5542981 | 0.75 | SOS1 (0.53) | IDO1TDO2HPGDHSD17B10KDM4E | |
| SCHEMBL1539296 | 0.73 | L3MBTL1 (0.53) | HTTLMNAPOLBALDH1A1MAPT | |
| SCHEMBL17604220 | 0.72 | HPGD (0.43) | IDO1TDO2HTTLMNAPOLB | |
| SCHEMBL11411112 | 0.71 | MEN1 (0.44) | HTTEGFRLMNAALDH1A1MAPT | |
| SCHEMBL8727116 | 0.70 | EGFR (0.45) | HTTEGFRLMNAERBB2MAPT | |
| SCHEMBL160145 | 0.70 | L3MBTL1 (0.46) | HTTLMNAPOLBALDH1A1MAPT | |
| SCHEMBL8725869 | 0.69 | EGFR (0.44) | HTTEGFRLMNAALDH1A1MAPT | |
| SCHEMBL29239940 | 0.68 | MEN1 (0.49) | HTTLMNAPOLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832091-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040705-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |