Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.54 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8732280 | 0.89 | CXCL8 (0.65) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8732216 | 0.88 | CXCL8 (0.64) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8733716 | 0.83 | PTGS2 (0.68) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8728772 | 0.83 | PTGS1 (0.51) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL2237360 | 0.82 | PTGS2 (0.77) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8726561 | 0.79 | PTGS2 (0.78) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL7685392 | 0.79 | PTGS2 (0.60) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8732264 | 0.78 | CXCL8 (0.56) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8461618 | 0.76 | PTGS2 (0.64) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8728761 | 0.74 | CXCL8 (0.52) | CXCL8AKR1B1PTGS1PTGS2GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783488-A4 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO (JP) | 1998-01-07 | — | — | EP | claimed |
| EP-0783488-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | claimed |
| WO-1996010013-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-04-04 | — | — | WO | claimed |