Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.68 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.68 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.68 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8726561 | 0.93 | PTGS2 (0.78) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL2237360 | 0.93 | PTGS2 (0.77) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL7685392 | 0.86 | PTGS2 (0.60) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8732264 | 0.85 | CXCL8 (0.56) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8458232 | 0.84 | PTGS1 (0.74) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8726526 | 0.83 | CXCL8 (0.54) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8461618 | 0.83 | PTGS2 (0.64) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8729681 | 0.82 | PTGS2 (0.70) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8731019 | 0.82 | PTGS2 (0.70) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8728761 | 0.81 | CXCL8 (0.52) | PTGS2PTGS1CXCL8AKR1B1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783488-A4 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO (JP) | 1998-01-07 | — | — | EP | claimed |
| EP-0783488-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | claimed |
| WO-1996010013-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-04-04 | — | — | WO | claimed |