Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 5/20 | 0.51 |
| ▸ | RARB | P10826 | 4/20 | 0.48 |
| ▸ | RARA | P10276 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12121775 | 0.88 | PTPN11 (0.60) | PTPN11RARBRARAPTPN1PTPN6 | |
| SCHEMBL28435821 | 0.87 | LMNA (0.57) | PTPN11CNR1CNR2MEN1NR1I2 | |
| SCHEMBL5827955 | 0.82 | LMNA (0.62) | PTPN11CNR1CNR2MEN1NR1I2 | |
| SCHEMBL27288709 | 0.81 | PTPN11 (0.74) | PTPN11RARBRARAPTPN1PTPN6 | |
| SCHEMBL13332125 | 0.80 | THRA (0.50) | PTPN11MEN1MAPTKMT2AKDM4E | |
| SCHEMBL29111485 | 0.79 | ESR1 (0.51) | PTPN11MEN1LMNAMAPTKMT2A | |
| SCHEMBL12121604 | 0.78 | ACLY (0.54) | PTPN11RARBRARAPTPN1ADRB1 | |
| SCHEMBL5222184 | 0.78 | HDAC3 (0.53) | CNR1CNR2LMNA | |
| SCHEMBL7366543 | 0.77 | LMNA (0.69) | PTPN11CNR1CNR2MEN1NR1I2 | |
| SCHEMBL14373016 | 0.77 | CNR2 (0.67) | CNR1CNR2MEN1NR1I2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817826-A | INHIBIT FORMATION OF PROSTAGLANDINS, LEUKOTRIENES; ANTIINFLAMMATION AGENTS | SHIONOGI & CO., LTD. (JP) | 1998-10-06 | — | — | US | disclosed |
| EP-0675114-A1 | OXAZOLINONE DERIVATIVE HAVING INTRACELLULAR PHOSPHOLIPASE A 2? INHIBITOR ACTIVITY | SHIONOGI & CO., LTD. (JP) | 1995-10-04 | — | — | EP | disclosed |