Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CALCRLCHRM1CHRM2CHRM3F2RMAOAMAOBMAP2K1MAP2K2NTRK1NTRK2NTRK3OPRD1OPRK1OPRM1P2RY12PKLRSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASLC18A2SLC6A2SLC6A3TLR7TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8dacAdacBdacCfolAftsImrcAmrcBmrdApolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmB1rpmB2rpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmHrpmIrpmJrpmJ2rpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsR1rpsR2rpsSrpsTrpsUrpsZykgMykgO
The experimentally established mechanism targets of Thymine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.79 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | DPYD | Q12882 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thymine SCHEMBL23794979 | 0.89 | ATAD2 (0.91) | ATAD2GAADPYDMAPTALDH1A1 | |
| Thymine SCHEMBL15323914 | 0.89 | ATAD2 (1.00) | ATAD2GAADPYDMAPTALDH1A1 | |
| Thymine SCHEMBL750450 | 0.89 | ATAD2 (1.00) | ATAD2GAADPYDMAPTALDH1A1 | |
| Thymine SCHEMBL5235 | 0.89 | — | — | |
| Thymine SCHEMBL17201833 | 0.89 | ATAD2 (1.00) | ATAD2GAADPYDMAPTALDH1A1 | |
| Thymine SCHEMBL3025204 | 0.87 | ATAD2 (0.86) | ATAD2GAADPYDMAPTALDH1A1 | |
| Thymine SCHEMBL8304490 | 0.87 | ATAD2 (0.86) | ATAD2GAADPYDMAPTALDH1A1 | |
| Thymine SCHEMBL8649294 | 0.87 | ATAD2 (0.95) | ATAD2GAADPYDMAPTALDH1A1 | |
| Thymine SCHEMBL935833 | 0.87 | ATAD2 (0.95) | ATAD2GAADPYDMAPTALDH1A1 | |
| Thymine SCHEMBL31403209 | 0.87 | ATAD2 (0.95) | ATAD2GAADPYDMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240076728-A1 | NOVEL METHOD OF COMBINED MOLECULAR CLAMPING AND ALLELE SPECIFIC qPCR TECHNOLOGY FOR KRAS G12C MUTATION DETECTION | SUN QING (US) | 2024-03-07 | — | — | US | disclosed |
| CN-1083455-C | Photocurable glycosaminoglycan derivatives, crosslinked glycosaminoglycans and method of production thereof | SEIKAGAKU KOGYO CO LTD (JP) | 2002-04-24 | — | — | CN | disclosed |
| US-5763504-A | PREVENTING CELL AND/OR TISSUE ADHESION WHEN APPLIED TO WOUNDS | SEIKAGAKU KOGYO KABUSHIKI KAISHA(SEIKAGAKU CORPORATION) (JP) | 1998-06-09 | — | — | US | disclosed |
| EP-0554898-B1 | Photocurable glycosaminoglycan derivatives, crosslinked glycosaminoglycans and method of production thereof | SEIKAGAKU KOGYO CO LTD (JP) | 1997-05-07 | — | — | EP | disclosed |
| US-5462976-A | Photocurable glycosaminoglycan derivatives, crosslinked glycosaminoglycans and method of production thereof | SEIKAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1995-10-31 | — | — | US | disclosed |
| CN-1075970-A | Photocurable medicine sugar aminoglycan derivative, crosslinked glycosaminoglycan and production method thereof | SEIKAGAKU KOGYO CO LTD (JP) | 1993-09-08 | — | — | CN | disclosed |
| EP-0554898-A2 | Photocurable glycosaminoglycan derivatives, crosslinked glycosaminoglycans and method of production thereof | SEIKAGAKU KOGYO KABUSHIKI KAISHA (SEIKAGAKU CORPORATION) (JP) | 1993-08-11 | — | — | EP | disclosed |