SCHEMBL872824

SCHEMBL872824

CCCCCCN=CCO

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
ALDH1A1 P00352 3/20 0.42
LMNA P02545 2/20 0.42
TSHR P16473 2/20 0.42
HSD17B10 Q99714 1/20 0.42
THRB P10828 3/20 0.38
NAAA Q02083 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MAPT P10636 2/20 0.37
HTT P42858 1/20 0.37
KDM4E B2RXH2 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
CA12 O43570 2/20 0.35
CA2 P00918 2/20 0.35
CA9 Q16790 2/20 0.35
SIGMAR1 Q99720 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2900135 1.00 MEN1 (0.43) MEN1KMT2AALDH1A1LMNATSHR
SCHEMBL21647611 1.00 MEN1 (0.43) MEN1KMT2AALDH1A1LMNATSHR
SCHEMBL28054343 1.00 MEN1 (0.43) MEN1KMT2AALDH1A1LMNATSHR
SCHEMBL28826404 1.00 MEN1 (0.43) MEN1KMT2AALDH1A1LMNATSHR
SCHEMBL28457008 1.00 MEN1 (0.43) MEN1KMT2AALDH1A1LMNATSHR
SCHEMBL28457026 1.00 MEN1 (0.43) MEN1KMT2AALDH1A1LMNATSHR
SCHEMBL287739 1.00 MEN1 (0.43) MEN1KMT2AALDH1A1LMNATSHR
SCHEMBL28462442 1.00 MEN1 (0.43) MEN1KMT2AALDH1A1LMNATSHR
Hydrochloric Acid SCHEMBL28261063 0.98 MEN1 (0.41) MEN1KMT2AALDH1A1LMNATSHR
SCHEMBL872485 0.98

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116370648-A Chemotherapeutic drug-polymer conjugate capable of triggering active transcellular transport and preparation method and application thereof 复旦大学 2023-07-04 CN claimed
JP-61134381-A None JP disclosed
US-20260146064-A1 PH-SENSITIVE MEMBRANE DISRUPTIVE PEPTIDES AND USE THEREOF SOUTH CHINA UNIVERSITY OF TECHNOLOGY (CN) 2026-05-28 US disclosed
US-12528903-B2 Block copolymer and micelle compositions and methods of use thereof THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2026-01-20 US disclosed
US-12091486-B2 Block copolymer and micelle compositions and methods of use thereof THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-09-17 US disclosed
EP-4313937-A1 IONIZABLE LIPIDS AND LIPID NANOPARTICLES COMPRISING SAID IONIZABLE LIPIDS FOR DELIVERY OF THERAPEUTIC AGENTS Universiteit Gent (BE) 2024-02-07 EP disclosed
CN-116370648-A Chemotherapeutic drug-polymer conjugate capable of triggering active transcellular transport and preparation method and application thereof 复旦大学 2023-07-04 CN disclosed
US-20230085899-A1 NOVEL BLOCK COPOLYMER AND MICELLE COMPOSITIONS AND METHODS OF USE THEREOF THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2023-03-23 US disclosed
WO-2022207938-A1 IONIZABLE LIPIDS AND LIPID NANOPARTICLES COMPRISING SAID IONIZABLE LIPIDS FOR DELIVERY OF THERAPEUTIC AGENTS UNIVERSITEIT GENT (BE) 2022-10-06 WO disclosed
US-20220226510-A1 STIMULI-RESPONSIVE NANOPARTICLES FOR BIOMEDICAL APPLICATIONS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-07-21 US disclosed
US-5457205-A Substituted thiazoles useful for treatment of diabetes DR. KARL THOMAE GMBH (DE) 1995-10-10 US disclosed
US-5232946-A Promoting weight gain and reduction of blood sugar and fat deposits in animals, feed efficiency DR. KARL THOMAE GMBH (DE) 1993-08-03 US disclosed
US-5219852-A Hypoglycemic agents, treatment of diabetes and obesity DR. KARL THOMAE GMBH (DE) 1993-06-15 US disclosed
US-5026702-A Enhances physical performance in animals, effective in lowering blood sugar, reducing body fat and lowering atherogenic lipoproteins DR. KARL THOMAE, GMBH (DE) 1991-06-25 US disclosed
US-4886814-A LOWER BLOOD SUGAR DR. KARL THOMAS GMBH (DE) 1989-12-12 US disclosed
JP-S61134381-A PRODUCTION OF 2-HEXAMETHYLENEIMINOETHYL ACRYLATE MITSUBISHI PETROCHEM CO LTD 1986-06-21 JP disclosed
US-4287209-A USEFUL AS METABOLIC REGULATORS, AND HERBICIDES SOCIETE DE RECHERCHES INDUSTRIELLES (S.O.R.I.) (FR) 1981-09-01 US disclosed
US-4235896-A Benzyl-phenoxy acid esters and hyperlipaemia compositions containing the same ORCHIMED S.A. (CH) 1980-11-25 US disclosed
US-4179515-A HYPOLIPEMIC, HYPOCHOLESTEROLEMIC, CHOLAGOGIC ORCHIMED S. A. (CH) 1979-12-18 US disclosed
US-4146385-A METABOLIC REGULATORS, CARDIOVASCULAR AGENTS, HERBICIDES SOCIETE DE RECHERCHES INDUSTRIELLES S.O.R.I. (FR) 1979-03-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230085899-A1 NOVEL BLOCK COPOLYMER AND MICELLE COMPOSITIONS AND METHODS OF USE THEREOF FOLR2, FOLR1, MPC2 MEN1 1278/4885KMT2A 1079/4885ALDH1A1 3441/4885
US-20260146064-A1 PH-SENSITIVE MEMBRANE DISRUPTIVE PEPTIDES AND USE THEREOF LNPK, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, YWHAZ MEN1 592/4885KMT2A 4382/4885ALDH1A1 4676/4885
US-12528903-B2 Block copolymer and micelle compositions and methods of use thereof PHOSPHO1, SGMS1, PCTP MEN1 279/4885KMT2A 1592/4885ALDH1A1 2708/4885
US-12091486-B2 Block copolymer and micelle compositions and methods of use thereof FOLR2, FOLR1, MPC2 MEN1 1114/4885KMT2A 930/4885ALDH1A1 3141/4885
US-20220226510-A1 STIMULI-RESPONSIVE NANOPARTICLES FOR BIOMEDICAL APPLICATIONS HSPA9, LRBA, AHSA1 MEN1 1698/4885KMT2A 4687/4885ALDH1A1 4542/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.