Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8728241 | 0.78 | POLB (0.40) | FLT3RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL7372881 | 0.77 | TP53 (0.37) | TP53MAPT | |
| SCHEMBL7365147 | 0.76 | FLT3 (0.42) | METFLT3RAB9ASMN1; SMN2TP53 | |
| SCHEMBL11012268 | 0.76 | MAPT (0.46) | METFLT3RAB9ASMN1; SMN2TP53 | |
| SCHEMBL11004327 | 0.70 | CASP3 (0.53) | RAB9ASMN1; SMN2TP53LMNAMAPT | |
| SCHEMBL73916 | 0.70 | MBD2 (0.58) | METFLT3RAB9ASMN1; SMN2TP53 | |
| SCHEMBL7368901 | 0.70 | LMNA (0.56) | RAB9ASMN1; SMN2TP53LMNAMAPT | |
| SCHEMBL84416 | 0.68 | RAB9A (0.64) | METFLT3RAB9ASMN1; SMN2TP53 | |
| SCHEMBL11011725 | 0.67 | MAPT (0.51) | METFLT3RAB9ASMN1; SMN2TP53 | |
| SCHEMBL10803156 | 0.66 | TP53 (0.52) | METRAB9ASMN1; SMN2TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237929-B1 | 3,5-DISUBSTITUTED PYROCATECHOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-02 | — | — | EP | disclosed |
| EP-0237929-A1 | 3,5-Disubstituted pyrocatechol derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1987-09-23 | — | — | EP | disclosed |