Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29441997 | 0.76 | ALDH1A1 (0.52) | ALDH1A1POLBTDP1L3MBTL1KIF11 | |
| SCHEMBL63469 | 0.76 | ALDH1A1 (0.52) | ALDH1A1POLBTDP1L3MBTL1KIF11 | |
| SCHEMBL7601747 | 0.75 | MPL (0.46) | ALDH1A1POLBTDP1L3MBTL1AXL | |
| SCHEMBL2000756 | 0.75 | HSD11B1 (0.46) | ALDH1A1POLBTDP1L3MBTL1AXL | |
| SCHEMBL8729161 | 0.75 | HSD11B1 (0.34) | ALDH1A1POLBTDP1L3MBTL1IDO1 | |
| Hydrogen Sulfide SCHEMBL28274662 | 0.73 | ALDH1A1 (0.50) | ALDH1A1POLBTDP1L3MBTL1KIF11 | |
| SCHEMBL1041748 | 0.73 | TAS2R14 (0.46) | ALDH1A1POLBTDP1L3MBTL1AXL | |
| SCHEMBL408969 | 0.73 | ALDH1A1 (0.39) | ALDH1A1POLBTDP1L3MBTL1AXL | |
| SCHEMBL396026 | 0.73 | POLB (0.44) | ALDH1A1POLBTDP1L3MBTL1AXL | |
| SCHEMBL21303635 | 0.73 | ALDH1A1 (0.39) | ALDH1A1POLBTDP1L3MBTL1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609058-B1 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-12-09 | — | — | EP | disclosed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0609058-A2 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-08-03 | — | — | EP | disclosed |