Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5795608 | 0.80 | POLB (0.36) | HSD11B1POLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL8729606 | 0.77 | HSD11B1 (0.33) | HSD11B1POLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL8728398 | 0.75 | ALDH1A1 (0.41) | HSD11B1POLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL2000756 | 0.75 | HSD11B1 (0.46) | HSD11B1POLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL4299413 | 0.74 | NOTUM (0.36) | HSD11B1POLBCES2GLAGAA | |
| Lithium SCHEMBL5691154 | 0.72 | HSD11B1 (0.44) | HSD11B1POLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL12310597 | 0.70 | GAA (0.32) | HSD11B1POLBALDH1A1CES2GLA | |
| SCHEMBL6157191 | 0.70 | HSD11B1 (0.40) | HSD11B1POLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL1041762 | 0.70 | SMN1; SMN2 (0.40) | HSD11B1POLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL17341739 | 0.69 | POLB (0.33) | POLBALDH1A1TDP1L3MBTL1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609058-B1 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-12-09 | — | — | EP | disclosed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0609058-A2 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-08-03 | — | — | EP | disclosed |