Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.31 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.31 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8728946 | 0.83 | CARM1 (0.37) | KCNH2CCR5CARM1PRMT6GNAI3 | |
| SCHEMBL2760188 | 0.82 | SMN1; SMN2 (0.42) | KCNH2ACHEBACE1CCR5BCHE | |
| SCHEMBL22878502 | 0.78 | PABPC1 (0.46) | KCNH2CARM1PRMT6GNAI3GNAO1 | |
| SCHEMBL8488055 | 0.77 | KCNH2 (0.40) | KCNH2AKT1 | |
| SCHEMBL5789303 | 0.77 | CARM1 (0.34) | CARM1PRMT6 | |
| SCHEMBL12464451 | 0.77 | ACHE (0.44) | KCNH2ACHE | |
| SCHEMBL24673647 | 0.75 | ROCK2 (0.39) | KCNH2ACHEBACE1CCR5BCHE | |
| SCHEMBL19723131 | 0.75 | KDM1A (0.42) | KCNH2CARM1PRMT6GNAI3GNAO1 | |
| SCHEMBL27969225 | 0.75 | KCNH2 (0.35) | KCNH2ACHEBACE1CCR5BCHE | |
| SCHEMBL4572196 | 0.75 | DPP7 (0.44) | KCNH2GNAI3GNAO1GNAI1DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624584-B1 | Piperazine derivatives useful as calmodulin inhibitors | DAIICHI SEIYAKU CO (JP) | 1998-08-19 | — | — | EP | disclosed |
| US-5681954-A | HAS CALMODULIN INHIBITORY ACTIVITY; USEFUL IN TREATING DISEASES OF THE CIRCULATORY ORGANS OR IN CEREBRAL REGION | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1997-10-28 | — | — | US | disclosed |
| EP-0624584-A1 | Piperazine derivatives useful as calmodolin inhibitors | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1994-11-17 | — | — | EP | disclosed |