SCHEMBL8729140

SCHEMBL8729140

O=P(O)(CCCOCc1ccccc1)COS(=O)(=O)c1ccc(Cl)cc1

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.38
AR P10275 1/20 0.37
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
GRM5 P41594 1/20 0.36
TSHR P16473 2/20 0.36
ALDH1A1 P00352 2/20 0.36
STS P08842 1/20 0.36
TP53 P04637 1/20 0.36
GAA P10253 1/20 0.36
PTGES O14684 1/20 0.35
KCNH2 Q12809 1/20 0.35
BCL2L1 Q07817 1/20 0.35
MCL1 Q07820 1/20 0.35
CYP2D6 P10635 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
PTGS1 P23219 1/20 0.35
PTGS2 P35354 1/20 0.35
FAAH O00519 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8758117 0.86 GAA (0.47) TSHRALDH1A1TP53GAAPTGES
SCHEMBL8758194 0.85 L3MBTL1 (0.47) PKMTP53GAAPTGESBCL2L1
SCHEMBL8732756 0.80 TDP1 (0.42) ARALDH1A1TP53GAATDP1
SCHEMBL8727363 0.76 CETP (0.42) TSHRKCNH2CYP2D6
SCHEMBL9056402 0.74 CYP2C19 (0.58) TSHRTDP1PTGS1PTGS2
SCHEMBL8727266 0.73 TSHR (0.49) TSHR
SCHEMBL8758259 0.73 PKM (0.38) PKMARNPC1RAB9AGRM5
SCHEMBL8583268 0.72 TDP1 (0.44) ALDH1A1TP53GAATDP1
SCHEMBL6555609 0.72 TSHR (0.45) PKMARTSHRALDH1A1TDP1
SCHEMBL3149080 0.71 CA2 (0.47) NPC1ALDH1A1GAATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5726165-A HYPOGLYCEMIC AGENTS; DIETETICS; GASTROINTESTINAL DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 1998-03-10 US disclosed
EP-0772585-A1 ARYLOXY AND ARYLTHIOPROPANOLAMINE DERIVATIVES USEFUL AS BETA 3-ADRENORECEPTOR AGONISTS AND ANTAGONISTS OF THE BETA 1 AND BETA 2-ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF SMITHKLINE BEECHAM PLC (GB) 1997-05-14 EP disclosed
WO-1996004234-A1 ARYLOXY ANDARYCTHIO PROPANOLAMINE DERIVATIVES USEFUL AS B3-ADRENORECEPTOR AGONISTS AND ANTAGONS OF THE B1 AND B2 ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF SMITHKLINE BEECHAM PLC (GB) 1996-02-15 WO disclosed
WO-1996004233-A1 ARYLOXY AND ARYLTHIOPROPANOLAMINE DERIVATIVES USEFUL AS BETA 3-ADRENORECEPTOR AGONISTS AND ANTAGONISTS OF THE BETA 1 AND BETA 2-ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF SMITHKLINE BEECHAM PLC (GB) 1996-02-15 WO disclosed