Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5795608 | 0.84 | POLB (0.36) | HSD11B1ALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL8729161 | 0.77 | HSD11B1 (0.34) | HSD11B1ALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL2000756 | 0.73 | HSD11B1 (0.46) | HSD11B1ALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL4299413 | 0.72 | NOTUM (0.36) | HSD11B1POLBMEN1KMT2A | |
| SCHEMBL7028820 | 0.72 | CES2 (0.34) | HSD11B1POLB | |
| Lithium SCHEMBL5691154 | 0.70 | HSD11B1 (0.44) | HSD11B1ALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL23628452 | 0.70 | GLA (0.33) | HSD11B1POLB | |
| SCHEMBL1263960 | 0.70 | NOTUM (0.50) | — | |
| SCHEMBL1053235 | 0.70 | HSD11B1 (0.30) | HSD11B1 | |
| SCHEMBL4542512 | 0.70 | KIF11 (0.36) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609058-B1 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-12-09 | — | — | EP | disclosed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0609058-A2 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-08-03 | — | — | EP | disclosed |