SCHEMBL8731574

SCHEMBL8731574

N=C(N)NC(=N)NNC(=N)NC(=N)N(Cc1ccc(Cl)cc1)c1ccc(Cl)cc1

nearest known ligand 0.40

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
BCL2A1 Q16548 3/20 0.39
CNR2 P34972 3/20 0.39
IDO1 P14902 4/20 0.36
CNR1 P21554 1/20 0.36
PDK2 Q15119 1/20 0.35
PDK4 Q16654 1/20 0.35
SIGMAR1 Q99720 3/20 0.33
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18762978 0.74 CYP3A4 (0.44) CNR2IDO1CNR1ALDH1A1
SCHEMBL8895093 0.73 SIGMAR1 (0.45) IDO1SIGMAR1ALDH1A1
SCHEMBL3025013 0.73 SIGMAR1 (0.36) IDO1SIGMAR1ALDH1A1
SCHEMBL28129340 0.72 NPC1 (0.46) IDO1ALDH1A1
Hydrochloric Acid SCHEMBL9615764 0.71 LMNA (0.37) IDO1SIGMAR1ALDH1A1
Hydrochloric Acid SCHEMBL17186270 0.71 NPC1 (0.45) IDO1ALDH1A1
Hydrochloric Acid SCHEMBL1937338 0.70 ALDH1A1 (0.47) IDO1SIGMAR1ALDH1A1
Hydrochloric Acid SCHEMBL1937395 0.70 ALDH1A1 (0.47) IDO1SIGMAR1ALDH1A1
SCHEMBL1741631 0.69 RAB9A (0.47) IDO1
SCHEMBL1040794 0.68 CYP2C9 (0.58) IDO1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998004143-A2 A PROCESS FOR THE DECONTAMINATION OF MEATS THE DOW CHEMICAL COMPANY (US) 1998-02-05 WO disclosed