Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 12/20 | 0.55 |
| ▸ | CTSK | P43235 | 4/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | KLK7 | P49862 | 1/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12046896 | 0.92 | CASP1 (0.56) | SYKCASP1CTSKCTSLCTSB | |
| SCHEMBL79537 | 0.89 | CASP1 (0.54) | SYKCASP1CTSKCTSLCTSB | |
| SCHEMBL17731584 | 0.89 | CASP1 (0.54) | SYKCASP1CTSKCTSLCTSB | |
| SCHEMBL79538 | 0.89 | CASP1 (0.54) | SYKCASP1CTSKCTSLCTSB | |
| SCHEMBL478289 | 0.89 | PPARA (0.57) | SYKCASP1CTSKCTSLCTSB | |
| SCHEMBL1143898 | 0.89 | PPARA (0.57) | SYKCASP1CTSKCTSLCTSB | |
| SCHEMBL2775895 | 0.89 | PPARA (0.57) | SYKCASP1CTSKCTSLCTSB | |
| SCHEMBL29398102 | 0.89 | SYK (0.57) | SYKCASP1CTSKCTSLCTSB | |
| SCHEMBL4256075 | 0.88 | KYNU (0.56) | SYKCASP1CTSKCTSLCTSB | |
| SCHEMBL19694832 | 0.88 | KYNU (0.56) | SYKCASP1CTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129381-B2 | Caspase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-06 | — | — | US | disclosed |
| US-20090281128-A1 | CASPASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281128-A1 | CASPASE INHIBITORS AND USES THEREOF | CASP1, CASP5, CASP3 | SYK 1687/4885CASP1 1/4885CTSK 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.