Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 1/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.62 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8728761 | 0.87 | CXCL8 (0.52) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8731019 | 0.83 | PTGS2 (0.70) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8729681 | 0.83 | PTGS2 (0.70) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8726561 | 0.83 | PTGS2 (0.78) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL2237360 | 0.83 | PTGS2 (0.77) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| Water SCHEMBL9275860 | 0.82 | PTGS2 (0.72) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8458232 | 0.80 | PTGS1 (0.74) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8726746 | 0.80 | PTGS2 (0.65) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8733603 | 0.80 | PTGS2 (0.68) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| Tolmetin SCHEMBL11325188 | 0.77 | PTGS2 (1.00) | CXCL8AKR1B1PTGS1PTGS2GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783488-A4 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO (JP) | 1998-01-07 | — | — | EP | claimed |
| EP-0783488-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | claimed |
| WO-1996010013-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-04-04 | — | — | WO | claimed |