SCHEMBL8733733

SCHEMBL8733733

Cc1ccc2c(c1)C(=O)CCC2=O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.52
MAOA P21397 1/20 0.52
ELANE P08246 1/20 0.50
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
CA4 P22748 1/20 0.47
CA7 P43166 1/20 0.47
CA9 Q16790 1/20 0.47
PARP10 Q53GL7 2/20 0.46
PARP11 Q9NR21 1/20 0.46
PARP1 P09874 1/20 0.46
METAP1 P53582 2/20 0.42
ACHE P22303 1/20 0.42
KDM4E B2RXH2 4/20 0.42
HTT P42858 2/20 0.42
ATM Q13315 2/20 0.42
HSD17B10 Q99714 2/20 0.42
CASP1 P29466 1/20 0.42
CASP7 P55210 1/20 0.42
ALDH1A1 P00352 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3254156 0.86 MAOB (0.52) MAOBMAOAELANECA1CA2
SCHEMBL27632859 0.82 CASP1 (0.59) MAOBMAOAPARP10PARP11PARP1
SCHEMBL423287 0.82 CASP1 (0.59) MAOBMAOAPARP10PARP11PARP1
SCHEMBL354988 0.82 PBRM1 (0.59) MAOBMAOAELANEPARP10PARP11
SCHEMBL30465799 0.82 PBRM1 (0.59) MAOBMAOAELANEPARP10PARP11
SCHEMBL29726014 0.82 CASP1 (0.59) MAOBMAOAPARP10PARP11PARP1
Hydrochloric Acid SCHEMBL7402731 0.80 CASP1 (0.57) MAOBMAOAPARP10PARP11PARP1
SCHEMBL14141748 0.78 PARP10 (0.45) MAOBMAOAELANECA1CA2
SCHEMBL17301350 0.77 TUBB4A (0.42) MAOBMAOAELANEPARP10PARP11
SCHEMBL6872249 0.74 CDK5 (0.49) PARP10PARP1KDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0876356-A1 USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF LABORATOIRE INNOTHERA Société Anonyme (FR) 1998-11-11 EP disclosed
WO-1997021684-A1 USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF LABORATOIRE INNOTHERA, SOCIETE ANONYME (FR) 1997-06-19 WO disclosed