Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 8/20 | 0.56 |
| ▸ | CA2 | P00918 | 8/20 | 0.56 |
| ▸ | CA4 | P22748 | 8/20 | 0.56 |
| ▸ | CA9 | Q16790 | 8/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633853 | 0.89 | MAPT (0.45) | CA1CA2CA4CA9PTGS2 | |
| SCHEMBL8630975 | 0.78 | PTGS2 (0.59) | CA1CA2CA4CA9PTGS2 | |
| SCHEMBL8733986 | 0.77 | PTGS2 (0.60) | CA1CA2CA4CA9PTGS2 | |
| SCHEMBL2850385 | 0.76 | CA2 (0.50) | CA1CA2CA4CA9PTGS2 | |
| SCHEMBL8629958 | 0.75 | POLB (0.55) | CA1CA2CA4CA9PTGS2 | |
| SCHEMBL8630977 | 0.72 | CA1 (0.49) | CA1CA2CA4CA9PTGS2 | |
| SCHEMBL2854620 | 0.72 | CA1 (0.43) | CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL2861572 | 0.72 | CA1 (0.49) | CA1CA2CA4CA9 | |
| SCHEMBL2859712 | 0.72 | CA1 (0.45) | CA1CA2CA4CA9PTGS2 | |
| SCHEMBL2852372 | 0.72 | MAPT (0.48) | CA1CA2CA4CA9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |